Drp1 activates ROS/HIF-1α/EZH2 and triggers mitochondrial fragmentation to deteriorate hypercalcemia-associated neuronal injury in mouse model of chronic kidney disease

Drp1 activates ROS/HIF-1α/EZH2 and triggers mitochondrial fragmentation to deteriorate hypercalcemia-associated neuronal injury in mouse model of chronic kidney disease

Abstract Background Chronic kidney disease (CKD), characterized as renal dysfunction, is regarded as a major public health problem which carries a high risk of cardiovascular diseases. The purpose of this study is to evaluate the functional significance of Drp1 in hypercalcemia-associated neuronal d...

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Bibliographic Details
Main Authors: Hongming Sun, Xitong Li, Xin Chen, Yingquan Xiong, Yaochen Cao, Ziqiang Wang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Neuroinflammation
Subjects:
Drp1
Chronic kidney disease
Hypercalcemia
Neuronal damage
Mitochondrial fragmentation
HIF-1α
Online Access:https://doi.org/10.1186/s12974-022-02542-7

Internet

https://doi.org/10.1186/s12974-022-02542-7

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