A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets
The orally disintegrating tablet (ODT) has shown vast potential as an alternative oral dosage form to conventional tablets wherein they can disintegrate rapidly (≤30 s) upon contact with saliva fluid and should have an acceptable mouthfeel as long as their weight doesn’t exceed 500 mg. However, owin...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/1/120 |
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| author | Essam A. Tawfik Mariagiovanna Scarpa Hend E. Abdelhakim Haitham A. Bukhary Duncan Q. M. Craig Susan A. Barker Mine Orlu |
| author_facet | Essam A. Tawfik Mariagiovanna Scarpa Hend E. Abdelhakim Haitham A. Bukhary Duncan Q. M. Craig Susan A. Barker Mine Orlu |
| author_sort | Essam A. Tawfik |
| collection | DOAJ |
| description | The orally disintegrating tablet (ODT) has shown vast potential as an alternative oral dosage form to conventional tablets wherein they can disintegrate rapidly (≤30 s) upon contact with saliva fluid and should have an acceptable mouthfeel as long as their weight doesn’t exceed 500 mg. However, owing to the bitterness of several active ingredients, there is a need to find a suitable alternative to ODTs that maintains their features and can be taste-masked more simply and inexpensively. Therefore, electrospun nanofibers and solvent-cast oral dispersible films (ODFs) are used in this study as potential OD formulations for prednisolone sodium phosphate (PSP) that is commercially available as ODTs. The encapsulation efficiency (EE%) of the ODFs was higher (≈100%) compared to the nanofibers (≈87%), while the disintegration time was considerably faster for the electrospun nanofibers (≈30 s) than the solvent-cast ODFs (≈700 s). Hence, accelerated release rate of PSP from the nanofibers was obtained, due to their higher surface area and characteristic surface morphology that permitted higher wettability and thus, faster erosion. Taste-assessment study using the electronic-tongue quantified the bitterness threshold of the drug and its aversiveness concentration (2.79 mM). Therefore, a taste-masking strategy would be useful when further formulating PSP as an OD formulation. |
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| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T04:21:17Z |
| publishDate | 2021-01-01 |
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| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c780b473707446d8beb4169c9909b9b32023-12-03T13:46:50ZengMDPI AGPharmaceutics1999-49232021-01-0113112010.3390/pharmaceutics13010120A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating TabletsEssam A. Tawfik0Mariagiovanna Scarpa1Hend E. Abdelhakim2Haitham A. Bukhary3Duncan Q. M. Craig4Susan A. Barker5Mine Orlu6National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology, P.O. Box 6086, Riyadh 11442, Saudi ArabiaDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKMedway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building Central Avenue, Chatham, Kent ME4 4TB, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKThe orally disintegrating tablet (ODT) has shown vast potential as an alternative oral dosage form to conventional tablets wherein they can disintegrate rapidly (≤30 s) upon contact with saliva fluid and should have an acceptable mouthfeel as long as their weight doesn’t exceed 500 mg. However, owing to the bitterness of several active ingredients, there is a need to find a suitable alternative to ODTs that maintains their features and can be taste-masked more simply and inexpensively. Therefore, electrospun nanofibers and solvent-cast oral dispersible films (ODFs) are used in this study as potential OD formulations for prednisolone sodium phosphate (PSP) that is commercially available as ODTs. The encapsulation efficiency (EE%) of the ODFs was higher (≈100%) compared to the nanofibers (≈87%), while the disintegration time was considerably faster for the electrospun nanofibers (≈30 s) than the solvent-cast ODFs (≈700 s). Hence, accelerated release rate of PSP from the nanofibers was obtained, due to their higher surface area and characteristic surface morphology that permitted higher wettability and thus, faster erosion. Taste-assessment study using the electronic-tongue quantified the bitterness threshold of the drug and its aversiveness concentration (2.79 mM). Therefore, a taste-masking strategy would be useful when further formulating PSP as an OD formulation.https://www.mdpi.com/1999-4923/13/1/120electrospinningelectrospun nanofiberssolvent-castingorodispersible films (ODFs), prednisolonedisintegrationdissolution |
| spellingShingle | Essam A. Tawfik Mariagiovanna Scarpa Hend E. Abdelhakim Haitham A. Bukhary Duncan Q. M. Craig Susan A. Barker Mine Orlu A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets Pharmaceutics electrospinning electrospun nanofibers solvent-casting orodispersible films (ODFs), prednisolone disintegration dissolution |
| title | A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets |
| title_full | A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets |
| title_fullStr | A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets |
| title_full_unstemmed | A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets |
| title_short | A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets |
| title_sort | potential alternative orodispersible formulation to prednisolone sodium phosphate orally disintegrating tablets |
| topic | electrospinning electrospun nanofibers solvent-casting orodispersible films (ODFs), prednisolone disintegration dissolution |
| url | https://www.mdpi.com/1999-4923/13/1/120 |
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