Tyrosine kinase signaling-independent MET-targeting with CAR-T cells

Tyrosine kinase signaling-independent MET-targeting with CAR-T cells

Abstract Background Recent progress in cancer immunotherapy encourages the expansion of chimeric antigen receptor (CAR) T cell therapy in solid tumors including hepatocellular carcinoma (HCC). Overexpression of MET receptor tyrosine kinase is common in HCC; however, MET inhibitors are effective only...

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Bibliographic Details
Main Authors: Anna Qin, Yuan Qin, Joseph Lee, Anna Musket, Mingyao Ying, Giedre Krenciute, Francesco M. Marincola, Zhi Q. Yao, Phillip R. Musich, Qian Xie
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
Hepatocellular carcinoma
MET tyrosine kinase receptor
Programmed cell death protein 1 (PD-1)
Chimeric antigen receptor T cell therapy
Cancer immunotherapy
Online Access:https://doi.org/10.1186/s12967-023-04521-9

Internet

https://doi.org/10.1186/s12967-023-04521-9

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