Genetically stable CRISPR-based kill switches for engineered microbes
Biocontainment is a key to developing safe genetically-engineered microbes (GEMs). Here the authors demonstrate genetically stable CRISPR-based kill switches that control GEMs’ viability in animal hosts, enabling their safe biomedical applications.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28163-5 |
| _version_ | 1828749840811556864 |
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| author | Austin G. Rottinghaus Aura Ferreiro Skye R. S. Fishbein Gautam Dantas Tae Seok Moon |
| author_facet | Austin G. Rottinghaus Aura Ferreiro Skye R. S. Fishbein Gautam Dantas Tae Seok Moon |
| author_sort | Austin G. Rottinghaus |
| collection | DOAJ |
| description | Biocontainment is a key to developing safe genetically-engineered microbes (GEMs). Here the authors demonstrate genetically stable CRISPR-based kill switches that control GEMs’ viability in animal hosts, enabling their safe biomedical applications. |
| first_indexed | 2024-12-10T20:29:09Z |
| format | Article |
| id | doaj.art-c781c73e86f744feb43e92b1032cd16e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T20:29:09Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c781c73e86f744feb43e92b1032cd16e2022-12-22T01:34:45ZengNature PortfolioNature Communications2041-17232022-02-0113111710.1038/s41467-022-28163-5Genetically stable CRISPR-based kill switches for engineered microbesAustin G. Rottinghaus0Aura Ferreiro1Skye R. S. Fishbein2Gautam Dantas3Tae Seok Moon4Department of Energy, Environmental and Chemical Engineering, Washington University in St. LouisThe Edison Family Center for Genome Sciences & Systems Biology, Washington University School of MedicineThe Edison Family Center for Genome Sciences & Systems Biology, Washington University School of MedicineThe Edison Family Center for Genome Sciences & Systems Biology, Washington University School of MedicineDepartment of Energy, Environmental and Chemical Engineering, Washington University in St. LouisBiocontainment is a key to developing safe genetically-engineered microbes (GEMs). Here the authors demonstrate genetically stable CRISPR-based kill switches that control GEMs’ viability in animal hosts, enabling their safe biomedical applications.https://doi.org/10.1038/s41467-022-28163-5 |
| spellingShingle | Austin G. Rottinghaus Aura Ferreiro Skye R. S. Fishbein Gautam Dantas Tae Seok Moon Genetically stable CRISPR-based kill switches for engineered microbes Nature Communications |
| title | Genetically stable CRISPR-based kill switches for engineered microbes |
| title_full | Genetically stable CRISPR-based kill switches for engineered microbes |
| title_fullStr | Genetically stable CRISPR-based kill switches for engineered microbes |
| title_full_unstemmed | Genetically stable CRISPR-based kill switches for engineered microbes |
| title_short | Genetically stable CRISPR-based kill switches for engineered microbes |
| title_sort | genetically stable crispr based kill switches for engineered microbes |
| url | https://doi.org/10.1038/s41467-022-28163-5 |
| work_keys_str_mv | AT austingrottinghaus geneticallystablecrisprbasedkillswitchesforengineeredmicrobes AT auraferreiro geneticallystablecrisprbasedkillswitchesforengineeredmicrobes AT skyersfishbein geneticallystablecrisprbasedkillswitchesforengineeredmicrobes AT gautamdantas geneticallystablecrisprbasedkillswitchesforengineeredmicrobes AT taeseokmoon geneticallystablecrisprbasedkillswitchesforengineeredmicrobes |