Allogeneic haematopoietic stem cell transplantation resets T‐ and B‐cell compartments in sickle cell disease patients

Allogeneic haematopoietic stem cell transplantation resets T‐ and B‐cell compartments in sickle cell disease patients

Abstract Objectives Allogeneic haematopoietic stem cell transplantation (allo‐HSCT) is the only currently available curative treatment for sickle cell disease (SCD). Here, we comprehensively evaluated the reconstitution of T‐ and B‐cell compartments in 29 SCD patients treated with allo‐HSCT and how...

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Main Authors: Luciana Ribeiro Jarduli‐Maciel, Júlia Teixeira Cottas de Azevedo, Emmanuel Clave, Thalita Cristina de Mello Costa, Lucas Coelho Marlière Arruda, Isabelle Fournier, Patrícia Vianna Bonini Palma, Keli Cristina Lima, Juliana Bernardes Elias, Ana Beatriz PL Stracieri, Fabiano Pieroni, Renato Cunha, Luiz Guilherme Darrigo‐Júnior, Carlos Eduardo Settani Grecco, Dimas Tadeu Covas, Ana Cristina Silva‐Pinto, Gil Cunha De Santis, Belinda Pinto Simões, Maria Carolina Oliveira, Antoine Toubert, Kelen Cristina Ribeiro Malmegrim
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
allogeneic haematopoietic stem cell transplantation
B‐cell neogenesis
peripheral homeostasis
sickle cell disease
T‐cell neogenesis
Online Access:https://doi.org/10.1002/cti2.1389

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