The Incidence of Oxaliplatin-Induced Peripheral Neurotoxicity at Khartoum Oncology Hospital: A Cross-Sectional Survey
Objective: Using oxaliplatin-based chemotherapy in the treatment of cancer patients can cause a unique form of acute and chronic peripheral neurotoxicities. This study mainly aims to assess the incidence of oxaliplatin-induced peripheral neuropathy (OXAIPN). Methods: A cross-sectional study among 12...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Asia-Pacific Journal of Oncology Nursing |
| Subjects: | |
| Online Access: | http://www.apjon.org/article.asp?issn=2347-5625;year=2020;volume=7;issue=3;spage=266;epage=272;aulast= |
| _version_ | 1797758869712142336 |
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| author | Nadeen T Ali Amel A Mohamed Bashir A Yousef |
| author_facet | Nadeen T Ali Amel A Mohamed Bashir A Yousef |
| author_sort | Nadeen T Ali |
| collection | DOAJ |
| description | Objective: Using oxaliplatin-based chemotherapy in the treatment of cancer patients can cause a unique form of acute and chronic peripheral neurotoxicities. This study mainly aims to assess the incidence of oxaliplatin-induced peripheral neuropathy (OXAIPN). Methods: A cross-sectional study among 121 patients treated with oxaliplatin-based chemotherapy was conducted during the period of January to April 2019 at Khartoum Oncology Hospital. The incidence of acute neurotoxicity was assessed using a descriptive questionnaire for most common hyperexcitability and transient symptoms, while the incidence of chronic neurotoxicity was measured by the 20-item European Organization for Research and Treatment of Cancer Quality of Life Questionnaire for patients with chemotherapy-induced peripheral neuropathy and graded by the National Cancer Institute's Common Terminology Criteria for Adverse Events, Version 4.03. Results: Acute and chronic OXAIPN were found in 49.6% and 41.3% of patients, respectively. Most of the patients who developed acute OXAIPN symptoms manifested cold-induced pharyngolaryngeal dysesthesias (73.3%) or perioral paresthesias (71.7%). No significant association exists between the severity of chronic neurotoxicity and basic demographics. Most (79.1%) of the patients did not inform the doctors about their complaints, and 43.5% of those who informed doctors did not take any medication to manage OXAIPN. Conclusions: This study exhibits that oxaliplatin-based chemotherapy can cause symptoms of peripheral neurotoxicity in most of the patients with colorectal or gastric cancer in the form of acute neurotoxicity or chronic neurotoxicity. |
| first_indexed | 2024-03-12T18:36:14Z |
| format | Article |
| id | doaj.art-c7826e052b1c44f597388fcc9b90f343 |
| institution | Directory Open Access Journal |
| issn | 2347-5625 2349-6673 |
| language | English |
| last_indexed | 2024-03-12T18:36:14Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asia-Pacific Journal of Oncology Nursing |
| spelling | doaj.art-c7826e052b1c44f597388fcc9b90f3432023-08-02T07:58:53ZengElsevierAsia-Pacific Journal of Oncology Nursing2347-56252349-66732020-01-017326627210.4103/apjon.apjon_12_20The Incidence of Oxaliplatin-Induced Peripheral Neurotoxicity at Khartoum Oncology Hospital: A Cross-Sectional SurveyNadeen T AliAmel A MohamedBashir A YousefObjective: Using oxaliplatin-based chemotherapy in the treatment of cancer patients can cause a unique form of acute and chronic peripheral neurotoxicities. This study mainly aims to assess the incidence of oxaliplatin-induced peripheral neuropathy (OXAIPN). Methods: A cross-sectional study among 121 patients treated with oxaliplatin-based chemotherapy was conducted during the period of January to April 2019 at Khartoum Oncology Hospital. The incidence of acute neurotoxicity was assessed using a descriptive questionnaire for most common hyperexcitability and transient symptoms, while the incidence of chronic neurotoxicity was measured by the 20-item European Organization for Research and Treatment of Cancer Quality of Life Questionnaire for patients with chemotherapy-induced peripheral neuropathy and graded by the National Cancer Institute's Common Terminology Criteria for Adverse Events, Version 4.03. Results: Acute and chronic OXAIPN were found in 49.6% and 41.3% of patients, respectively. Most of the patients who developed acute OXAIPN symptoms manifested cold-induced pharyngolaryngeal dysesthesias (73.3%) or perioral paresthesias (71.7%). No significant association exists between the severity of chronic neurotoxicity and basic demographics. Most (79.1%) of the patients did not inform the doctors about their complaints, and 43.5% of those who informed doctors did not take any medication to manage OXAIPN. Conclusions: This study exhibits that oxaliplatin-based chemotherapy can cause symptoms of peripheral neurotoxicity in most of the patients with colorectal or gastric cancer in the form of acute neurotoxicity or chronic neurotoxicity.http://www.apjon.org/article.asp?issn=2347-5625;year=2020;volume=7;issue=3;spage=266;epage=272;aulast=colorectal cancergastric cancerkhartoum oncology hospitaloxaliplatinperipheral neurotoxicity |
| spellingShingle | Nadeen T Ali Amel A Mohamed Bashir A Yousef The Incidence of Oxaliplatin-Induced Peripheral Neurotoxicity at Khartoum Oncology Hospital: A Cross-Sectional Survey Asia-Pacific Journal of Oncology Nursing colorectal cancer gastric cancer khartoum oncology hospital oxaliplatin peripheral neurotoxicity |
| title | The Incidence of Oxaliplatin-Induced Peripheral Neurotoxicity at Khartoum Oncology Hospital: A Cross-Sectional Survey |
| title_full | The Incidence of Oxaliplatin-Induced Peripheral Neurotoxicity at Khartoum Oncology Hospital: A Cross-Sectional Survey |
| title_fullStr | The Incidence of Oxaliplatin-Induced Peripheral Neurotoxicity at Khartoum Oncology Hospital: A Cross-Sectional Survey |
| title_full_unstemmed | The Incidence of Oxaliplatin-Induced Peripheral Neurotoxicity at Khartoum Oncology Hospital: A Cross-Sectional Survey |
| title_short | The Incidence of Oxaliplatin-Induced Peripheral Neurotoxicity at Khartoum Oncology Hospital: A Cross-Sectional Survey |
| title_sort | incidence of oxaliplatin induced peripheral neurotoxicity at khartoum oncology hospital a cross sectional survey |
| topic | colorectal cancer gastric cancer khartoum oncology hospital oxaliplatin peripheral neurotoxicity |
| url | http://www.apjon.org/article.asp?issn=2347-5625;year=2020;volume=7;issue=3;spage=266;epage=272;aulast= |
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