A Combined <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway
Since skeletal muscle atrophy resulting from various causes accelerates the progression of several diseases, its prevention should help maintain health and quality of life. A range of natural materials have been investigated for their potential preventive effects against muscle atrophy. Here, ethano...
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MDPI AG
2022-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/20/3245 |
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| author | Hyun-Ji Oh Heegu Jin Byung-Yong Kim Ok-Hwan Lee Boo-Yong Lee |
| author_facet | Hyun-Ji Oh Heegu Jin Byung-Yong Kim Ok-Hwan Lee Boo-Yong Lee |
| author_sort | Hyun-Ji Oh |
| collection | DOAJ |
| description | Since skeletal muscle atrophy resulting from various causes accelerates the progression of several diseases, its prevention should help maintain health and quality of life. A range of natural materials have been investigated for their potential preventive effects against muscle atrophy. Here, ethanol extracts of <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> were concentrated and dried, and mixed at a ratio of 7:3 to create the mixture CHDT. We then evaluated the potential for CHDT to prevent muscle atrophy and explored the mechanisms involved. CHDT was orally administered to C57BL/6 mice daily for 30 days, and dexamethasone (Dex) was intraperitoneally injected daily to induce muscle atrophy from 14 days after the start of oral administration. We found that CHDT prevented the Dex-induced reductions in muscle strength, mass, and fiber size, likely by upregulating the Akt/mTOR signaling pathway. In addition, CHDT reduced the Dex-induced increase in the serum concentrations of pro-inflammatory cytokines, which directly induce the degradation of muscle proteins. These findings suggest that CHDT could serve as a natural food supplement for the prevention of muscle atrophy. |
| first_indexed | 2024-03-09T20:29:29Z |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:29:29Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c7842d541c224db2a37054b4a798fbb12023-11-23T23:27:54ZengMDPI AGCells2073-44092022-10-011120324510.3390/cells11203245A Combined <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling PathwayHyun-Ji Oh0Heegu Jin1Byung-Yong Kim2Ok-Hwan Lee3Boo-Yong Lee4Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam 13488, KoreaDepartment of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam 13488, KoreaCH Labs, Seoul 07249, KoreaDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, KoreaDepartment of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam 13488, KoreaSince skeletal muscle atrophy resulting from various causes accelerates the progression of several diseases, its prevention should help maintain health and quality of life. A range of natural materials have been investigated for their potential preventive effects against muscle atrophy. Here, ethanol extracts of <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> were concentrated and dried, and mixed at a ratio of 7:3 to create the mixture CHDT. We then evaluated the potential for CHDT to prevent muscle atrophy and explored the mechanisms involved. CHDT was orally administered to C57BL/6 mice daily for 30 days, and dexamethasone (Dex) was intraperitoneally injected daily to induce muscle atrophy from 14 days after the start of oral administration. We found that CHDT prevented the Dex-induced reductions in muscle strength, mass, and fiber size, likely by upregulating the Akt/mTOR signaling pathway. In addition, CHDT reduced the Dex-induced increase in the serum concentrations of pro-inflammatory cytokines, which directly induce the degradation of muscle proteins. These findings suggest that CHDT could serve as a natural food supplement for the prevention of muscle atrophy.https://www.mdpi.com/2073-4409/11/20/3245<i>Angelica gigas</i><i>Artemisia dracunculus</i>dexamethasone-induced muscle atrophyAkt/mTOR signaling pathway |
| spellingShingle | Hyun-Ji Oh Heegu Jin Byung-Yong Kim Ok-Hwan Lee Boo-Yong Lee A Combined <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway Cells <i>Angelica gigas</i> <i>Artemisia dracunculus</i> dexamethasone-induced muscle atrophy Akt/mTOR signaling pathway |
| title | A Combined <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
| title_full | A Combined <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
| title_fullStr | A Combined <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
| title_full_unstemmed | A Combined <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
| title_short | A Combined <i>Angelica gigas</i> and <i>Artemisia dracunculus</i> Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
| title_sort | combined i angelica gigas i and i artemisia dracunculus i extract prevents dexamethasone induced muscle atrophy in mice through the akt mtor foxo3a signaling pathway |
| topic | <i>Angelica gigas</i> <i>Artemisia dracunculus</i> dexamethasone-induced muscle atrophy Akt/mTOR signaling pathway |
| url | https://www.mdpi.com/2073-4409/11/20/3245 |
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