A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants

A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants

The emergence of resistance to currently available anti-influenza drugs has heightened the need for antivirals with novel mechanisms of action. The influenza A virus (IAV) nucleoprotein (NP) is highly conserved and essential for the formation of viral ribonucleoprotein (vRNP), which serves as the te...

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Bibliographic Details
Main Authors: Juliann Nzembi Makau, Ken Watanabe, Hiroki Otaki, Satoshi Mizuta, Takeshi Ishikawa, Yuji O. Kamatari, Noriyuki Nishida
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Viruses
Subjects:
4-hydroxyquinolinone
antiviral
nucleoprotein
oligomerization
resistance
Online Access:https://www.mdpi.com/1999-4915/12/3/337

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