Cognitive dysfunction in Multiple Sclerosis
In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-05-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00074/full |
| _version_ | 1811269162047111168 |
|---|---|
| author | Joana eGuimarães Joana eGuimarães Maria José eSá Maria José eSá |
| author_facet | Joana eGuimarães Joana eGuimarães Maria José eSá Maria José eSá |
| author_sort | Joana eGuimarães |
| collection | DOAJ |
| description | In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes particularly important. In this review the authors address: the cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing and visual spatial abilities); the physiopathological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance; the most used tests and batteries for neuropsychological assessment; therapeutic strategies to improve cognitive abilities. |
| first_indexed | 2024-04-12T21:37:11Z |
| format | Article |
| id | doaj.art-c784fa51ac05404da6e2f2542a2ff599 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T21:37:11Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c784fa51ac05404da6e2f2542a2ff5992022-12-22T03:15:52ZengFrontiers Media S.A.Frontiers in Neurology1664-22952012-05-01310.3389/fneur.2012.0007423493Cognitive dysfunction in Multiple SclerosisJoana eGuimarães0Joana eGuimarães1Maria José eSá2Maria José eSá3MS Clinic, Department of Neurology, Centro Hospitalar São JoãoFaculty of Medicine, University of PortoMS Clinic, Department of Neurology, Centro Hospitalar São JoãoFaculty of Health Sciences, University Fernando PessoaIn Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes particularly important. In this review the authors address: the cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing and visual spatial abilities); the physiopathological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance; the most used tests and batteries for neuropsychological assessment; therapeutic strategies to improve cognitive abilities.http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00074/fullMultiple Sclerosiscognition domainsphysiopathologicalbrain MRIdisease evoluationneuropsychological assessment |
| spellingShingle | Joana eGuimarães Joana eGuimarães Maria José eSá Maria José eSá Cognitive dysfunction in Multiple Sclerosis Frontiers in Neurology Multiple Sclerosis cognition domains physiopathological brain MRI disease evoluation neuropsychological assessment |
| title | Cognitive dysfunction in Multiple Sclerosis |
| title_full | Cognitive dysfunction in Multiple Sclerosis |
| title_fullStr | Cognitive dysfunction in Multiple Sclerosis |
| title_full_unstemmed | Cognitive dysfunction in Multiple Sclerosis |
| title_short | Cognitive dysfunction in Multiple Sclerosis |
| title_sort | cognitive dysfunction in multiple sclerosis |
| topic | Multiple Sclerosis cognition domains physiopathological brain MRI disease evoluation neuropsychological assessment |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00074/full |
| work_keys_str_mv | AT joanaeguimaraes cognitivedysfunctioninmultiplesclerosis AT joanaeguimaraes cognitivedysfunctioninmultiplesclerosis AT mariajoseesa cognitivedysfunctioninmultiplesclerosis AT mariajoseesa cognitivedysfunctioninmultiplesclerosis |