IND-2, a Quinoline Derivative, Inhibits the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress, Apoptosis and Inhibiting Topoisomerase II

IND-2, a Quinoline Derivative, Inhibits the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress, Apoptosis and Inhibiting Topoisomerase II

In men, prostate cancer (PC) is the most frequently diagnosed cancer, causing an estimated 375,000 deaths globally. Currently, existing therapies for the treatment of PC, notably metastatic cases, have limited efficacy due to drug resistance and problematic adverse effects. Therefore, it is imperati...

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Bibliographic Details
Main Authors: Swapnaa Balaji, Rabin Neupane, Saloni Malla, Rahul Khupse, Haneen Amawi, Shikha Kumari, Diwakar Bastihalli Tukaramrao, Srestha Chattopadhyay, Charles R. Ashby, Sai H. S. Boddu, Chandrabose Karthikeyan, Piyush Trivedi, Dayanidhi Raman, Amit K. Tiwari
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Life
Subjects:
prostate cancer
apoptosis
quinoline derivative
IND-2
oxidative stress
mitotic catastrophe
Online Access:https://www.mdpi.com/2075-1729/12/11/1879

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