Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic pain
Chronic pain is a disease of long-lasting pain with unpleasant feelings mediated by central and (or) peripheral sensitization, its duration usually lasts more than 3 months or longer than the expected recovery time. The patients with chronic pain are manifested with enhanced sensitivity to noxious a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1041006/full |
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| author | Wei-Dong Lai Song Wang Wen-Ting You Si-Jia Chen Jun-Jun Wen Cun-Rui Yuan Meng-Jia Zheng Yan Jin Jie Yu Cheng-Ping Wen |
| author_facet | Wei-Dong Lai Song Wang Wen-Ting You Si-Jia Chen Jun-Jun Wen Cun-Rui Yuan Meng-Jia Zheng Yan Jin Jie Yu Cheng-Ping Wen |
| author_sort | Wei-Dong Lai |
| collection | DOAJ |
| description | Chronic pain is a disease of long-lasting pain with unpleasant feelings mediated by central and (or) peripheral sensitization, its duration usually lasts more than 3 months or longer than the expected recovery time. The patients with chronic pain are manifested with enhanced sensitivity to noxious and non-noxious stimuli. Due to an incomplete understanding of the mechanisms, patients are commonly insensitive to the treatment of first line analgesic medicine in clinic. Thus, the exploration of non-opioid-dependent analgesia are needed. Recent studies have shown that “sinomenine,” the main active ingredient in the natural plant “sinomenium acutum (Thunb.) Rehd. Et Wils,” has a powerful inhibitory effect on chronic pain, but its underlying mechanism still needs to be further elucidated. A growing number of studies have shown that various immune cells such as T cells, B cells, macrophages, astrocytes and microglia, accompanied with the relative inflammatory factors and neuropeptides, are involved in the pathogenesis of chronic pain. Notably, the interaction of the immune system and sensory neurons is essential for the development of central and (or) peripheral sensitization, as well as the progression and maintenance of chronic pain. Based on the effects of sinomenine on immune cells and their subsets, this review mainly focused on describing the potential analgesic effects of sinomenine, with rationality of regulating the neuroimmune interaction. |
| first_indexed | 2024-04-11T05:39:31Z |
| format | Article |
| id | doaj.art-c7860597dcd74324b61131669727c9eb |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T05:39:31Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-c7860597dcd74324b61131669727c9eb2022-12-22T09:48:21ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-12-011010.3389/fcell.2022.10410061041006Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic painWei-Dong Lai0Song Wang1Wen-Ting You2Si-Jia Chen3Jun-Jun Wen4Cun-Rui Yuan5Meng-Jia Zheng6Yan Jin7Jie Yu8Cheng-Ping Wen9School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Pharmacy, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, ChinaSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaXinhua Hospital of Zhejiang Province, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaChronic pain is a disease of long-lasting pain with unpleasant feelings mediated by central and (or) peripheral sensitization, its duration usually lasts more than 3 months or longer than the expected recovery time. The patients with chronic pain are manifested with enhanced sensitivity to noxious and non-noxious stimuli. Due to an incomplete understanding of the mechanisms, patients are commonly insensitive to the treatment of first line analgesic medicine in clinic. Thus, the exploration of non-opioid-dependent analgesia are needed. Recent studies have shown that “sinomenine,” the main active ingredient in the natural plant “sinomenium acutum (Thunb.) Rehd. Et Wils,” has a powerful inhibitory effect on chronic pain, but its underlying mechanism still needs to be further elucidated. A growing number of studies have shown that various immune cells such as T cells, B cells, macrophages, astrocytes and microglia, accompanied with the relative inflammatory factors and neuropeptides, are involved in the pathogenesis of chronic pain. Notably, the interaction of the immune system and sensory neurons is essential for the development of central and (or) peripheral sensitization, as well as the progression and maintenance of chronic pain. Based on the effects of sinomenine on immune cells and their subsets, this review mainly focused on describing the potential analgesic effects of sinomenine, with rationality of regulating the neuroimmune interaction.https://www.frontiersin.org/articles/10.3389/fcell.2022.1041006/fullsinomeninesensory neuronsimmune cellsglial cellschronic pain |
| spellingShingle | Wei-Dong Lai Song Wang Wen-Ting You Si-Jia Chen Jun-Jun Wen Cun-Rui Yuan Meng-Jia Zheng Yan Jin Jie Yu Cheng-Ping Wen Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic pain Frontiers in Cell and Developmental Biology sinomenine sensory neurons immune cells glial cells chronic pain |
| title | Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic pain |
| title_full | Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic pain |
| title_fullStr | Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic pain |
| title_full_unstemmed | Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic pain |
| title_short | Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic pain |
| title_sort | sinomenine regulates immune cell subsets potential neuro immune intervene for precise treatment of chronic pain |
| topic | sinomenine sensory neurons immune cells glial cells chronic pain |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1041006/full |
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