Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties
The heterogeneity of the mesenchymal stem/stromal cells (MSCs) population poses a challenge to researchers and clinicians, especially those observed at the population level. What is more, the lack of precise evidences regarding MSCs developmental origin even further complicate this issue. As the ava...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2023/1842958 |
| _version_ | 1797672245475147776 |
|---|---|
| author | Agnieszka Smolinska Aleksandra Bzinkowska Paulina Rybkowska Magdalena Chodkowska Anna Sarnowska |
| author_facet | Agnieszka Smolinska Aleksandra Bzinkowska Paulina Rybkowska Magdalena Chodkowska Anna Sarnowska |
| author_sort | Agnieszka Smolinska |
| collection | DOAJ |
| description | The heterogeneity of the mesenchymal stem/stromal cells (MSCs) population poses a challenge to researchers and clinicians, especially those observed at the population level. What is more, the lack of precise evidences regarding MSCs developmental origin even further complicate this issue. As the available evidences indicate several possible pathways of MSCs formation, this diverse origin may be reflected in the unique subsets of cells found within the MSCs population. Such populations differ in specialization degree, proliferation, and immunomodulatory properties or exhibit other additional properties such as increased angiogenesis capacity. In this review article, we attempted to identify such outstanding populations according to the specific surface antigens or intracellular markers. Described groups were characterized depending on their specialization and potential therapeutic application. The reports presented here cover a wide variety of properties found in the recent literature, which is quite scarce for many candidates mentioned in this article. Even though the collected information would allow for better targeting of specific subpopulations in regenerative medicine to increase the effectiveness of MSC-based therapies. |
| first_indexed | 2024-03-11T21:27:14Z |
| format | Article |
| id | doaj.art-c78781536a9b4cceae556d398ab37b30 |
| institution | Directory Open Access Journal |
| issn | 1687-9678 |
| language | English |
| last_indexed | 2024-03-11T21:27:14Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj.art-c78781536a9b4cceae556d398ab37b302023-09-28T00:00:07ZengHindawi LimitedStem Cells International1687-96782023-01-01202310.1155/2023/1842958Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique PropertiesAgnieszka Smolinska0Aleksandra Bzinkowska1Paulina Rybkowska2Magdalena Chodkowska3Anna Sarnowska4Translational Platform for Regenerative MedicineTranslational Platform for Regenerative MedicineTranslational Platform for Regenerative MedicineTranslational Platform for Regenerative MedicineTranslational Platform for Regenerative MedicineThe heterogeneity of the mesenchymal stem/stromal cells (MSCs) population poses a challenge to researchers and clinicians, especially those observed at the population level. What is more, the lack of precise evidences regarding MSCs developmental origin even further complicate this issue. As the available evidences indicate several possible pathways of MSCs formation, this diverse origin may be reflected in the unique subsets of cells found within the MSCs population. Such populations differ in specialization degree, proliferation, and immunomodulatory properties or exhibit other additional properties such as increased angiogenesis capacity. In this review article, we attempted to identify such outstanding populations according to the specific surface antigens or intracellular markers. Described groups were characterized depending on their specialization and potential therapeutic application. The reports presented here cover a wide variety of properties found in the recent literature, which is quite scarce for many candidates mentioned in this article. Even though the collected information would allow for better targeting of specific subpopulations in regenerative medicine to increase the effectiveness of MSC-based therapies.http://dx.doi.org/10.1155/2023/1842958 |
| spellingShingle | Agnieszka Smolinska Aleksandra Bzinkowska Paulina Rybkowska Magdalena Chodkowska Anna Sarnowska Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties Stem Cells International |
| title | Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties |
| title_full | Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties |
| title_fullStr | Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties |
| title_full_unstemmed | Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties |
| title_short | Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties |
| title_sort | promising markers in the context of mesenchymal stem stromal cells subpopulations with unique properties |
| url | http://dx.doi.org/10.1155/2023/1842958 |
| work_keys_str_mv | AT agnieszkasmolinska promisingmarkersinthecontextofmesenchymalstemstromalcellssubpopulationswithuniqueproperties AT aleksandrabzinkowska promisingmarkersinthecontextofmesenchymalstemstromalcellssubpopulationswithuniqueproperties AT paulinarybkowska promisingmarkersinthecontextofmesenchymalstemstromalcellssubpopulationswithuniqueproperties AT magdalenachodkowska promisingmarkersinthecontextofmesenchymalstemstromalcellssubpopulationswithuniqueproperties AT annasarnowska promisingmarkersinthecontextofmesenchymalstemstromalcellssubpopulationswithuniqueproperties |