Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

Abstract Background Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Her...

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Bibliographic Details
Main Authors: Muhammad Hasan Bashari, Fengjuan Fan, Sonia Vallet, Martin Sattler, Melissa Arn, Claudia Luckner-Minden, Henning Schulze-Bergkamen, Inka Zörnig, Frederik Marme, Andreas Schneeweiss, Michael H. Cardone, Joseph T. Opferman, Dirk Jäger, Klaus Podar
Format: Article
Language:English
Published: BMC 2016-02-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Myeloid cell leukemia-1
Hypoxia
Apoptosis
Online Access:https://doi.org/10.1186/s13058-016-0686-4

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