Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting BRG1 to activate Nrf2/HO-1 signaling pathway

Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting BRG1 to activate Nrf2/HO-1 signaling pathway

Oxidative stress is an important pathogenic factor in ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC), further impairing the entire colon. Intestinal epithelial cells (IECs) are crucial components of innate immunity and play an important role in maintaining intestinal barrier...

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Bibliographic Details
Main Authors: Xue-jun Wang, Dan Zhang, Yan-ting Yang, Xiao-ying Li, Hong-na Li, Xiao-peng Zhang, Jun-yi Long, Yun-qiong Lu, Li Liu, Guang Yang, Jie Liu, Jue Hong, Huan-gan Wu, Xiao-peng Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
ulcerative colitis (UC)
colitis-associated colorectal cancer (CAC)
oxidative stress
miR-222-3p
BRG1/Nrf2/HO-1 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1089809/full

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