A computational spatial whole-Cell model for hepatitis B viral infection and drug interactions
Abstract Despite a vaccine, hepatitis B virus (HBV) remains a world-wide source of infections and deaths. We develop a whole-cell computational platform combining spatial and kinetic models describing the infection cycle of HBV in a hepatocyte host. We simulate key parts of the infection cycle with...
Main Authors: | Zhaleh Ghaemi, Oluwadara Nafiu, Emad Tajkhorshid, Martin Gruebele, Jianming Hu |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-12-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-45998-0 |
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