Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices
Background: A left ventricular assist device (LVAD) is normally contraindicated in significant aortic regurgitation (AR) and requires intraoperative valve repair or exclusion. Nevertheless, AR can coexist with an LVAD, so a valid question when asked might still be of clinical significance. The purpo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422016000020 |
| _version_ | 1818179698935463936 |
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| author | Yoo Seok Kim Eun-Hye Kim Hyeong-Gyun Kim Eun Bo Shim Kwang-Soup Song Ki Moo Lim |
| author_facet | Yoo Seok Kim Eun-Hye Kim Hyeong-Gyun Kim Eun Bo Shim Kwang-Soup Song Ki Moo Lim |
| author_sort | Yoo Seok Kim |
| collection | DOAJ |
| description | Background: A left ventricular assist device (LVAD) is normally contraindicated in significant aortic regurgitation (AR) and requires intraoperative valve repair or exclusion. Nevertheless, AR can coexist with an LVAD, so a valid question when asked might still be of clinical significance. The purpose of this study is to analyze the effects of valve regurgitation on the pumping efficacy of continuous and pulsatile LVADs with a computational method.
Methods: A cardiovascular model was developed based on the Windkessel model, which reflects the hemodynamic flow resistance and the blood wall elasticity. Using the Windkessel model, important cardiovascular components, such as the right atrium, right ventricle, pulmonary artery, pulmonary vein, left atrium (LA), left ventricle (LV), aorta, and branching blood vessels, were expressed.
Results: In the case of AR, continuous and pulsatile LVADs improved cardiac output and reduced mechanical load slightly. In the case of mitral regurgitation, the LVADs improved cardiac output (cardiac outputs were about 5 L/min regardless of the severity of regurgitation) and reduced afterload significantly.
Conclusion: AR reduced both continuous and pulsatile LVAD function significantly while mitral regurgitation did not affect their pumping efficacy. |
| first_indexed | 2024-12-11T21:08:01Z |
| format | Article |
| id | doaj.art-c7900be3b5e34467bc1a93dc6bf627d7 |
| institution | Directory Open Access Journal |
| issn | 2213-4220 |
| language | English |
| last_indexed | 2024-12-11T21:08:01Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj.art-c7900be3b5e34467bc1a93dc6bf627d72022-12-22T00:50:49ZengElsevierIntegrative Medicine Research2213-42202016-03-0151222910.1016/j.imr.2016.01.001Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devicesYoo Seok Kim0Eun-Hye Kim1Hyeong-Gyun Kim2Eun Bo Shim3Kwang-Soup Song4Ki Moo Lim5Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, KoreaDepartment of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, KoreaDepartment of Radiological Science, Far East University, Eumseong, KoreaDepartment of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, KoreaDepartment of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, KoreaDepartment of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, KoreaBackground: A left ventricular assist device (LVAD) is normally contraindicated in significant aortic regurgitation (AR) and requires intraoperative valve repair or exclusion. Nevertheless, AR can coexist with an LVAD, so a valid question when asked might still be of clinical significance. The purpose of this study is to analyze the effects of valve regurgitation on the pumping efficacy of continuous and pulsatile LVADs with a computational method. Methods: A cardiovascular model was developed based on the Windkessel model, which reflects the hemodynamic flow resistance and the blood wall elasticity. Using the Windkessel model, important cardiovascular components, such as the right atrium, right ventricle, pulmonary artery, pulmonary vein, left atrium (LA), left ventricle (LV), aorta, and branching blood vessels, were expressed. Results: In the case of AR, continuous and pulsatile LVADs improved cardiac output and reduced mechanical load slightly. In the case of mitral regurgitation, the LVADs improved cardiac output (cardiac outputs were about 5 L/min regardless of the severity of regurgitation) and reduced afterload significantly. Conclusion: AR reduced both continuous and pulsatile LVAD function significantly while mitral regurgitation did not affect their pumping efficacy.http://www.sciencedirect.com/science/article/pii/S2213422016000020aortic regurgitationleft ventricular assist devicemitral regurgitationregurgitation severityWindkessel model |
| spellingShingle | Yoo Seok Kim Eun-Hye Kim Hyeong-Gyun Kim Eun Bo Shim Kwang-Soup Song Ki Moo Lim Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices Integrative Medicine Research aortic regurgitation left ventricular assist device mitral regurgitation regurgitation severity Windkessel model |
| title | Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices |
| title_full | Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices |
| title_fullStr | Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices |
| title_full_unstemmed | Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices |
| title_short | Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices |
| title_sort | mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices |
| topic | aortic regurgitation left ventricular assist device mitral regurgitation regurgitation severity Windkessel model |
| url | http://www.sciencedirect.com/science/article/pii/S2213422016000020 |
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