Unilateral upper limb chorea associated with hyperthyroidism: A case report and literature review

Chorea, a hyperkinetic syndrome, is generally reported in patients with Huntington's disease (HD), hyperglycemia, and other diseases but occasionally occurs in patients with Grave's disease. Here, we report a 44-year-old woman presenting with a 1-year history of involuntary movements with...

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Main Authors: Wei Chen, Bin Wu, Hongna An, Kaiying Zheng, Daming Zhai, Jiahua Zang, Xiaobing Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Neurology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.1074156/full
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author Wei Chen
Bin Wu
Hongna An
Kaiying Zheng
Daming Zhai
Jiahua Zang
Xiaobing Wu
author_facet Wei Chen
Bin Wu
Hongna An
Kaiying Zheng
Daming Zhai
Jiahua Zang
Xiaobing Wu
author_sort Wei Chen
collection DOAJ
description Chorea, a hyperkinetic syndrome, is generally reported in patients with Huntington's disease (HD), hyperglycemia, and other diseases but occasionally occurs in patients with Grave's disease. Here, we report a 44-year-old woman presenting with a 1-year history of involuntary movements with a known history of primary hyperthyroidism. Physical examination revealed the continuous, rapid, irregular, and spontaneous choreic movement of her right arm. Laboratory investigations demonstrated increased triiodothyronine (T3) and free thyroxine (FT4) and suppressed thyroid-stimulating hormone (TSH) levels. An electroencephalogram and brain magnetic resonance imaging were normal. After antithyroid treatment, the patient achieved complete remission. Our case indicated that hemichorea might initially manifest hyperthyroidism. Therefore, thyroid function tests should be routinely performed in patients with chorea.
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spelling doaj.art-c792b7f879c847c9a51bc58dc3ceafd12022-12-22T16:41:13ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-12-011310.3389/fneur.2022.10741561074156Unilateral upper limb chorea associated with hyperthyroidism: A case report and literature reviewWei ChenBin WuHongna AnKaiying ZhengDaming ZhaiJiahua ZangXiaobing WuChorea, a hyperkinetic syndrome, is generally reported in patients with Huntington's disease (HD), hyperglycemia, and other diseases but occasionally occurs in patients with Grave's disease. Here, we report a 44-year-old woman presenting with a 1-year history of involuntary movements with a known history of primary hyperthyroidism. Physical examination revealed the continuous, rapid, irregular, and spontaneous choreic movement of her right arm. Laboratory investigations demonstrated increased triiodothyronine (T3) and free thyroxine (FT4) and suppressed thyroid-stimulating hormone (TSH) levels. An electroencephalogram and brain magnetic resonance imaging were normal. After antithyroid treatment, the patient achieved complete remission. Our case indicated that hemichorea might initially manifest hyperthyroidism. Therefore, thyroid function tests should be routinely performed in patients with chorea.https://www.frontiersin.org/articles/10.3389/fneur.2022.1074156/fullchoreainvoluntary movementhyperthyroidismGraves' diseaseinitial presentation
spellingShingle Wei Chen
Bin Wu
Hongna An
Kaiying Zheng
Daming Zhai
Jiahua Zang
Xiaobing Wu
Unilateral upper limb chorea associated with hyperthyroidism: A case report and literature review
Frontiers in Neurology
chorea
involuntary movement
hyperthyroidism
Graves' disease
initial presentation
title Unilateral upper limb chorea associated with hyperthyroidism: A case report and literature review
title_full Unilateral upper limb chorea associated with hyperthyroidism: A case report and literature review
title_fullStr Unilateral upper limb chorea associated with hyperthyroidism: A case report and literature review
title_full_unstemmed Unilateral upper limb chorea associated with hyperthyroidism: A case report and literature review
title_short Unilateral upper limb chorea associated with hyperthyroidism: A case report and literature review
title_sort unilateral upper limb chorea associated with hyperthyroidism a case report and literature review
topic chorea
involuntary movement
hyperthyroidism
Graves' disease
initial presentation
url https://www.frontiersin.org/articles/10.3389/fneur.2022.1074156/full
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