Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems
The main challenges in developing zeolites as cosmetic drug delivery systems are their cytotoxicities and the formation of drug-loading pore structures. In this study, Au-decorated zeolite nanocomposites were synthesized as an epidermal delivery system. Thus, 50 nm-sized Au nanoparticles were succes...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/2/66 |
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| author | Seungyeon Lee Geunjeong Lee Giyoung Jeon Hayeong Lee Suhyeon Park Youngju Sohn Youngkum Park Seongwoo Ryu |
| author_facet | Seungyeon Lee Geunjeong Lee Giyoung Jeon Hayeong Lee Suhyeon Park Youngju Sohn Youngkum Park Seongwoo Ryu |
| author_sort | Seungyeon Lee |
| collection | DOAJ |
| description | The main challenges in developing zeolites as cosmetic drug delivery systems are their cytotoxicities and the formation of drug-loading pore structures. In this study, Au-decorated zeolite nanocomposites were synthesized as an epidermal delivery system. Thus, 50 nm-sized Au nanoparticles were successfully deposited on zeolite 13X (super cage (α) and sodalite (β) cage structures) using the Turkevich method. Various cosmetic drugs, such as niacinamide, sulforaphane, and adenosine, were loaded under in vitro and in vivo observations. The Au-decorated zeolite nanocomposites exhibited effective cosmetic drug-loading efficiencies of 3.5 to 22.5 wt% under various conditions. For in vitro cytotoxic observations, B16F10 cells were treated with various cosmetic drugs. Niacinamide, sulforaphane, and adenosine-loaded Au-decorated zeolite nanocomposites exhibited clear cell viability of over 80%. Wrinkle improvement and a reduction in melanin content on the skin surface were observed in vivo. The adenosine delivery system exhibited an enhanced wrinkle improvement of 203% compared to 0.04 wt% of the pure adenosine system. The niacinamide- and sulforaphane-loaded Au-decorated zeolite nanocomposites decreased the skin surface melanin content by 123% and 222%, respectively, compared to 2 and 0.01 wt% of pure niacinamide and sulforaphane systems, respectively. As a result, Au-decorated zeolite nanocomposites show great potential as cosmetic drug epidermal delivery systems for both anti-aging and lightening effects. |
| first_indexed | 2024-03-11T08:37:12Z |
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| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T08:37:12Z |
| publishDate | 2023-01-01 |
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| series | Journal of Functional Biomaterials |
| spelling | doaj.art-c79309be7278462785bfb38af50460ef2023-11-16T21:24:12ZengMDPI AGJournal of Functional Biomaterials2079-49832023-01-011426610.3390/jfb14020066Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery SystemsSeungyeon Lee0Geunjeong Lee1Giyoung Jeon2Hayeong Lee3Suhyeon Park4Youngju Sohn5Youngkum Park6Seongwoo Ryu7Department of Materials Science and Engineering, The University of Suwon, 17 Wauan-Gil, Bongdam-Eup, Hwaseong-si 18323, Gyeonggi-do, Republic of KoreaGragem Co., Ltd. 21999, Room1009, 10F, Meet you all Tower Main 12, Geatbeol-ro, Yeonsu-gu, Incheon 21990, Republic of KoreaDepartment of Materials Science and Engineering, The University of Suwon, 17 Wauan-Gil, Bongdam-Eup, Hwaseong-si 18323, Gyeonggi-do, Republic of KoreaDepartment of Materials Science and Engineering, The University of Suwon, 17 Wauan-Gil, Bongdam-Eup, Hwaseong-si 18323, Gyeonggi-do, Republic of KoreaGragem Co., Ltd. 21999, Room1009, 10F, Meet you all Tower Main 12, Geatbeol-ro, Yeonsu-gu, Incheon 21990, Republic of KoreaGragem Co., Ltd. 21999, Room1009, 10F, Meet you all Tower Main 12, Geatbeol-ro, Yeonsu-gu, Incheon 21990, Republic of KoreaGragem Co., Ltd. 21999, Room1009, 10F, Meet you all Tower Main 12, Geatbeol-ro, Yeonsu-gu, Incheon 21990, Republic of KoreaDepartment of Materials Science and Engineering, The University of Suwon, 17 Wauan-Gil, Bongdam-Eup, Hwaseong-si 18323, Gyeonggi-do, Republic of KoreaThe main challenges in developing zeolites as cosmetic drug delivery systems are their cytotoxicities and the formation of drug-loading pore structures. In this study, Au-decorated zeolite nanocomposites were synthesized as an epidermal delivery system. Thus, 50 nm-sized Au nanoparticles were successfully deposited on zeolite 13X (super cage (α) and sodalite (β) cage structures) using the Turkevich method. Various cosmetic drugs, such as niacinamide, sulforaphane, and adenosine, were loaded under in vitro and in vivo observations. The Au-decorated zeolite nanocomposites exhibited effective cosmetic drug-loading efficiencies of 3.5 to 22.5 wt% under various conditions. For in vitro cytotoxic observations, B16F10 cells were treated with various cosmetic drugs. Niacinamide, sulforaphane, and adenosine-loaded Au-decorated zeolite nanocomposites exhibited clear cell viability of over 80%. Wrinkle improvement and a reduction in melanin content on the skin surface were observed in vivo. The adenosine delivery system exhibited an enhanced wrinkle improvement of 203% compared to 0.04 wt% of the pure adenosine system. The niacinamide- and sulforaphane-loaded Au-decorated zeolite nanocomposites decreased the skin surface melanin content by 123% and 222%, respectively, compared to 2 and 0.01 wt% of pure niacinamide and sulforaphane systems, respectively. As a result, Au-decorated zeolite nanocomposites show great potential as cosmetic drug epidermal delivery systems for both anti-aging and lightening effects.https://www.mdpi.com/2079-4983/14/2/66Au-decorated zeolitebiocompatible nanocompositeanti-aginglightening |
| spellingShingle | Seungyeon Lee Geunjeong Lee Giyoung Jeon Hayeong Lee Suhyeon Park Youngju Sohn Youngkum Park Seongwoo Ryu Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems Journal of Functional Biomaterials Au-decorated zeolite biocompatible nanocomposite anti-aging lightening |
| title | Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems |
| title_full | Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems |
| title_fullStr | Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems |
| title_full_unstemmed | Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems |
| title_short | Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems |
| title_sort | anti aging and lightening effects of au decorated zeolite based biocompatible nanocomposites in epidermal delivery systems |
| topic | Au-decorated zeolite biocompatible nanocomposite anti-aging lightening |
| url | https://www.mdpi.com/2079-4983/14/2/66 |
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