Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study
Introduction The growing worldwide prevalence of Alzheimer’s disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also prevalent in the ageing population and is increasingly recognised as a risk factor and an early sign of AD. The ALFASleep project aim...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e067159.full |
| _version_ | 1797783890603016192 |
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| author | Henrik Zetterberg Kaj Blennow José Luis Molinuevo Andreea Radoi Carolina Minguillón Karine Fauria Carme Deulofeu Marc Suárez-Calvet Oriol Grau-Rivera Alex Iranzo Iva Knezevic Núria Tort-Colet Laura Stankeviciute Laura Hernández Sherezade Fuentes-Julián Israel Turull David Fusté Gonzalo Sánchez-Benavides Eider M Arenaza-Urquijo Sebastian C Holst Pilar Garcés Thomas Mueggler Aurora Arqueros Juan Domingo Gispert |
| author_facet | Henrik Zetterberg Kaj Blennow José Luis Molinuevo Andreea Radoi Carolina Minguillón Karine Fauria Carme Deulofeu Marc Suárez-Calvet Oriol Grau-Rivera Alex Iranzo Iva Knezevic Núria Tort-Colet Laura Stankeviciute Laura Hernández Sherezade Fuentes-Julián Israel Turull David Fusté Gonzalo Sánchez-Benavides Eider M Arenaza-Urquijo Sebastian C Holst Pilar Garcés Thomas Mueggler Aurora Arqueros Juan Domingo Gispert |
| author_sort | Henrik Zetterberg |
| collection | DOAJ |
| description | Introduction The growing worldwide prevalence of Alzheimer’s disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also prevalent in the ageing population and is increasingly recognised as a risk factor and an early sign of AD. The ALFASleep project aims to characterise sleep with subjective and objective measurements in cognitively unimpaired middle/late middle-aged adults at increased risk of AD who are phenotyped with fluid and neuroimaging AD biomarkers. This will contribute to a better understanding of the pathophysiological mechanisms linking sleep with AD, thereby paving the way for the development of non-invasive biomarkers and preventive strategies targeting sleep.Methods and analysis We will invite 200 participants enrolled in the ALFA+ (for ALzheimer and FAmilies) prospective observational study to join the ALFASleep study. ALFA+ participants are cognitively unimpaired middle-aged/late middle-aged adults who are followed up every 3 years with a comprehensive set of evaluations including neuropsychological tests, blood and cerebrospinal fluid (CSF) sampling, and MRI and positron emission tomography acquisition. ALFASleep participants will be additionally characterised with actigraphy and CSF–orexin-A measurements, and a subset (n=90) will undergo overnight polysomnography. We will test associations of sleep measurements and CSF–orexin-A with fluid biomarkers of AD and glial activation, neuroimaging outcomes and cognitive performance. In case we found any associations, we will test whether changes in AD and/or glial activation markers mediate the association between sleep and neuroimaging or cognitive outcomes and whether sleep mediates associations between CSF–orexin-A and AD biomarkers.Ethics and dissemination The ALFASleep study protocol has been approved by the independent Ethics Committee Parc de Salut Mar, Barcelona (2018/8207/I). All participants have signed a written informed consent before their inclusion (approved by the same ethics committee). Study findings will be presented at national and international conferences and submitted for publication in peer-reviewed journals.Trial registration number NCT04932473. |
| first_indexed | 2024-03-13T00:33:17Z |
| format | Article |
| id | doaj.art-c793807a0174443da3ac6afb35420871 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-13T00:33:17Z |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-c793807a0174443da3ac6afb354208712023-07-10T10:30:06ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2022-067159Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational studyHenrik Zetterberg0Kaj Blennow1José Luis Molinuevo2Andreea Radoi3Carolina Minguillón4Karine Fauria5Carme Deulofeu6Marc Suárez-Calvet7Oriol Grau-Rivera8Alex Iranzo9Iva Knezevic10Núria Tort-Colet11Laura Stankeviciute12Laura Hernández13Sherezade Fuentes-Julián14Israel Turull15David Fusté16Gonzalo Sánchez-Benavides17Eider M Arenaza-Urquijo18Sebastian C Holst19Pilar Garcés20Thomas Mueggler21Aurora Arqueros22Juan Domingo Gispert238 Hong Kong Center for Neurodegenerative Diseases, Hong Kong, People`s Republic of ChinaDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden4 BarcelonaBeta Brain Research Center, Fundació Pasqual Maragall, Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, Spain1Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, Spain2 EASL CLIF Consortium, European Foundation for the Study of Chronic Liver Failure; EF CLIF, Barcelona, SpainIMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain11 Neurological Tissue Bank of the Biobanc-Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainCentro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainF Hoffmann-La Roche, Basel, SwitzerlandF Hoffmann-La Roche, Basel, SwitzerlandF Hoffmann-La Roche, Basel, SwitzerlandNeurology Service, Hospital Clínic de Barcelona and Institut D`Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainBarcelonaβeta Brain Research Center, Barcelona, SpainIntroduction The growing worldwide prevalence of Alzheimer’s disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also prevalent in the ageing population and is increasingly recognised as a risk factor and an early sign of AD. The ALFASleep project aims to characterise sleep with subjective and objective measurements in cognitively unimpaired middle/late middle-aged adults at increased risk of AD who are phenotyped with fluid and neuroimaging AD biomarkers. This will contribute to a better understanding of the pathophysiological mechanisms linking sleep with AD, thereby paving the way for the development of non-invasive biomarkers and preventive strategies targeting sleep.Methods and analysis We will invite 200 participants enrolled in the ALFA+ (for ALzheimer and FAmilies) prospective observational study to join the ALFASleep study. ALFA+ participants are cognitively unimpaired middle-aged/late middle-aged adults who are followed up every 3 years with a comprehensive set of evaluations including neuropsychological tests, blood and cerebrospinal fluid (CSF) sampling, and MRI and positron emission tomography acquisition. ALFASleep participants will be additionally characterised with actigraphy and CSF–orexin-A measurements, and a subset (n=90) will undergo overnight polysomnography. We will test associations of sleep measurements and CSF–orexin-A with fluid biomarkers of AD and glial activation, neuroimaging outcomes and cognitive performance. In case we found any associations, we will test whether changes in AD and/or glial activation markers mediate the association between sleep and neuroimaging or cognitive outcomes and whether sleep mediates associations between CSF–orexin-A and AD biomarkers.Ethics and dissemination The ALFASleep study protocol has been approved by the independent Ethics Committee Parc de Salut Mar, Barcelona (2018/8207/I). All participants have signed a written informed consent before their inclusion (approved by the same ethics committee). Study findings will be presented at national and international conferences and submitted for publication in peer-reviewed journals.Trial registration number NCT04932473.https://bmjopen.bmj.com/content/12/12/e067159.full |
| spellingShingle | Henrik Zetterberg Kaj Blennow José Luis Molinuevo Andreea Radoi Carolina Minguillón Karine Fauria Carme Deulofeu Marc Suárez-Calvet Oriol Grau-Rivera Alex Iranzo Iva Knezevic Núria Tort-Colet Laura Stankeviciute Laura Hernández Sherezade Fuentes-Julián Israel Turull David Fusté Gonzalo Sánchez-Benavides Eider M Arenaza-Urquijo Sebastian C Holst Pilar Garcés Thomas Mueggler Aurora Arqueros Juan Domingo Gispert Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study BMJ Open |
| title | Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study |
| title_full | Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study |
| title_fullStr | Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study |
| title_full_unstemmed | Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study |
| title_short | Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study |
| title_sort | exploring cognitive and biological correlates of sleep quality and their potential links with alzheimer s disease alfasleep project protocol for an observational study |
| url | https://bmjopen.bmj.com/content/12/12/e067159.full |
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