Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on <i>E. coli</i>

Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on <i>E. coli</i>

Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs is still a topic of great debate. This work demonstrates that the initial interaction between the Gram-negative <i>E...

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Bibliographic Details
Main Authors: Martin Jakubec, Fredrik G. Rylandsholm, Philip Rainsford, Mitchell Silk, Maxim Bril’kov, Tone Kristoffersen, Eric Juskewitz, Johanna U. Ericson, John Sigurd M. Svendsen
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomolecules
Subjects:
AMP
SPR
NMR
liposomes
LPS
lipid binding
Online Access:https://www.mdpi.com/2218-273X/13/7/1155

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