Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study
Abstract Background To describe objectively the possible structural changes of the macula and optic nerve head in the free eyes of unilateral cured retinoblastoma patients and, also after enucleation using spectral domain optical coherence tomography. Methods A cross sectional study involving 60 pat...
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-017-0650-9 |
| _version_ | 1819076174513438720 |
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| author | Azza Mohamed Ahmed Said Ahmed Mohamed Elbayomi Ashraf Abdelsalam Kandeel Shaat |
| author_facet | Azza Mohamed Ahmed Said Ahmed Mohamed Elbayomi Ashraf Abdelsalam Kandeel Shaat |
| author_sort | Azza Mohamed Ahmed Said |
| collection | DOAJ |
| description | Abstract Background To describe objectively the possible structural changes of the macula and optic nerve head in the free eyes of unilateral cured retinoblastoma patients and, also after enucleation using spectral domain optical coherence tomography. Methods A cross sectional study involving 60 patients subdivided into three groups; 15 unilateral RB patients in whom enucleation was indicated as a sole treatment performed earlier in life [(study group (I)], 15 unilateral RB patients who had completely regressed disease with a preserved eye [(study group (II)] and 30 age and sex matched healthy controls. The remaining and free eyes in study groups and right eyes of control group had full ophthalmological examination, static automated perimetry and optical coherence tomography of the macula and optic nerve head. Results In study group (II); a significant thinning of total macula, central fovea, ganglion cell layer (GCL), ganglion cell complex (GCC), and some sectors of outer nuclear layer (P- values ≤0.05) was found with no significant difference in peripapillary nerve fiber layer (pRNFL) thickness and optic nerve head parameters compared to the control group and the study group (I). A significantly thickened total macula, GCL, GCC, and pRNFL in study group (I) compared to study group (II). Thickened pRNFL was significantly correlated to standard automated perimetry pattern deviations. No significant difference was found between study group (I) and control group. Conclusion Retinoblastoma eyes characterized by thinning of central fovea, GCL, GCC compared to the control group. After unilateral enucleation, increased GCC and pRNFL thicknesses were detected compared to retinoblastoma group. |
| first_indexed | 2024-12-21T18:37:07Z |
| format | Article |
| id | doaj.art-c7952ac7598740e4b3e0bf1c9b47e485 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-21T18:37:07Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-c7952ac7598740e4b3e0bf1c9b47e4852022-12-21T18:54:07ZengBMCBMC Ophthalmology1471-24152017-12-0117111310.1186/s12886-017-0650-9Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography studyAzza Mohamed Ahmed Said0Ahmed Mohamed Elbayomi1Ashraf Abdelsalam Kandeel Shaat2Ophthalmology Department, Faculty of Medicine, Ain Shams UniversityOphthalmology Department, Faculty of Medicine, Ain Shams UniversityOphthalmology Department, Faculty of Medicine, Ain Shams UniversityAbstract Background To describe objectively the possible structural changes of the macula and optic nerve head in the free eyes of unilateral cured retinoblastoma patients and, also after enucleation using spectral domain optical coherence tomography. Methods A cross sectional study involving 60 patients subdivided into three groups; 15 unilateral RB patients in whom enucleation was indicated as a sole treatment performed earlier in life [(study group (I)], 15 unilateral RB patients who had completely regressed disease with a preserved eye [(study group (II)] and 30 age and sex matched healthy controls. The remaining and free eyes in study groups and right eyes of control group had full ophthalmological examination, static automated perimetry and optical coherence tomography of the macula and optic nerve head. Results In study group (II); a significant thinning of total macula, central fovea, ganglion cell layer (GCL), ganglion cell complex (GCC), and some sectors of outer nuclear layer (P- values ≤0.05) was found with no significant difference in peripapillary nerve fiber layer (pRNFL) thickness and optic nerve head parameters compared to the control group and the study group (I). A significantly thickened total macula, GCL, GCC, and pRNFL in study group (I) compared to study group (II). Thickened pRNFL was significantly correlated to standard automated perimetry pattern deviations. No significant difference was found between study group (I) and control group. Conclusion Retinoblastoma eyes characterized by thinning of central fovea, GCL, GCC compared to the control group. After unilateral enucleation, increased GCC and pRNFL thicknesses were detected compared to retinoblastoma group.http://link.springer.com/article/10.1186/s12886-017-0650-9RetinoblastomaEnucleationGanglion cell complexPeripapillary nerve fiber layer |
| spellingShingle | Azza Mohamed Ahmed Said Ahmed Mohamed Elbayomi Ashraf Abdelsalam Kandeel Shaat Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study BMC Ophthalmology Retinoblastoma Enucleation Ganglion cell complex Peripapillary nerve fiber layer |
| title | Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study |
| title_full | Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study |
| title_fullStr | Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study |
| title_full_unstemmed | Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study |
| title_short | Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study |
| title_sort | structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma an optical coherence tomography study |
| topic | Retinoblastoma Enucleation Ganglion cell complex Peripapillary nerve fiber layer |
| url | http://link.springer.com/article/10.1186/s12886-017-0650-9 |
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