Prognostic Significance of the L3 Skeletal Muscle Index and Advanced Lung Cancer Inflammation Index in Elderly Patients with Esophageal Cancer
Xiang Tan,1,* Huajian Peng,1,* Peixin Gu,2 Mingwu Chen,1 Yongyong Wang1 1Department of Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Neurology, The First Affiliate...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-04-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/prognostic-significance-of-the-l3-skeletal-muscle-index-and-advanced-l-peer-reviewed-article-CMAR |
| _version_ | 1818966166123577344 |
|---|---|
| author | Tan X Peng H Gu P Chen M Wang Y |
| author_facet | Tan X Peng H Gu P Chen M Wang Y |
| author_sort | Tan X |
| collection | DOAJ |
| description | Xiang Tan,1,* Huajian Peng,1,* Peixin Gu,2 Mingwu Chen,1 Yongyong Wang1 1Department of Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mingwu Chen; Yongyong Wang Department of Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Shuang Yong Road 6, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaEmail chen535@126.com; wangyongyong@stu.gxmu.edu.cnObjective: To evaluate the correlation between the advanced lung cancer inflammation index (ALI) and the L3 skeletal muscle index (L3SMI) and their prognostic value in elderly patients with esophageal cancer (EC).Materials and Methods: The clinical data of 158 elderly patients with EC were collected retrospectively. The L3SMI measures the area of skeletal muscle at the level of the third lumbar (L3) vertebra using computed tomography (CT). A high L3SMI and low L3SMI group were created using sex-based quartiles. The ALI, prognostic nutrition index (PNI), and geriatric nutrition risk index (GNRI) were calculated according to standard laboratory protocols.Results: The CT diagnostic criteria for senile sarcopenia in South China are height ≤ 32.96 cm2/m2 for females and height ≤ 35.4 cm2/m2 for males. The logistic regression analysis showed that a low L3SMI was significantly associated with a low ALI. Survival analysis revealed EC patients with a low L3SMI and a low ALI had poorer overall survival (OS) than patients with a high L3SMI and a high ALI. Univariate and multivariate Cox analyses showed that the L3SMI and ALI were independent predictors of EC prognosis in elderly individuals.Conclusion: There was a significant correlation between the PNI, GNRI, ALI, and L3SMI. Overall, our findings show the L3SMI and ALI are clinical indicators that can potentially be used to independently predict the prognosis of elderly EC patients and display good predictive value.Keywords: esophageal cancer, sarcopenia, L3 skeletal muscle index, survival, advanced lung cancer inflammation index |
| first_indexed | 2024-12-20T13:28:35Z |
| format | Article |
| id | doaj.art-c7953cd4146e4ac79045017b9ada1cf0 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-20T13:28:35Z |
| publishDate | 2021-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-c7953cd4146e4ac79045017b9ada1cf02022-12-21T19:39:11ZengDove Medical PressCancer Management and Research1179-13222021-04-01Volume 133133314363765Prognostic Significance of the L3 Skeletal Muscle Index and Advanced Lung Cancer Inflammation Index in Elderly Patients with Esophageal CancerTan XPeng HGu PChen MWang YXiang Tan,1,* Huajian Peng,1,* Peixin Gu,2 Mingwu Chen,1 Yongyong Wang1 1Department of Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mingwu Chen; Yongyong Wang Department of Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Shuang Yong Road 6, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaEmail chen535@126.com; wangyongyong@stu.gxmu.edu.cnObjective: To evaluate the correlation between the advanced lung cancer inflammation index (ALI) and the L3 skeletal muscle index (L3SMI) and their prognostic value in elderly patients with esophageal cancer (EC).Materials and Methods: The clinical data of 158 elderly patients with EC were collected retrospectively. The L3SMI measures the area of skeletal muscle at the level of the third lumbar (L3) vertebra using computed tomography (CT). A high L3SMI and low L3SMI group were created using sex-based quartiles. The ALI, prognostic nutrition index (PNI), and geriatric nutrition risk index (GNRI) were calculated according to standard laboratory protocols.Results: The CT diagnostic criteria for senile sarcopenia in South China are height ≤ 32.96 cm2/m2 for females and height ≤ 35.4 cm2/m2 for males. The logistic regression analysis showed that a low L3SMI was significantly associated with a low ALI. Survival analysis revealed EC patients with a low L3SMI and a low ALI had poorer overall survival (OS) than patients with a high L3SMI and a high ALI. Univariate and multivariate Cox analyses showed that the L3SMI and ALI were independent predictors of EC prognosis in elderly individuals.Conclusion: There was a significant correlation between the PNI, GNRI, ALI, and L3SMI. Overall, our findings show the L3SMI and ALI are clinical indicators that can potentially be used to independently predict the prognosis of elderly EC patients and display good predictive value.Keywords: esophageal cancer, sarcopenia, L3 skeletal muscle index, survival, advanced lung cancer inflammation indexhttps://www.dovepress.com/prognostic-significance-of-the-l3-skeletal-muscle-index-and-advanced-l-peer-reviewed-article-CMAResophageal cancersarcopenial3 skeletal muscle indexsurvivaladvanced lung cancer inflammation index. |
| spellingShingle | Tan X Peng H Gu P Chen M Wang Y Prognostic Significance of the L3 Skeletal Muscle Index and Advanced Lung Cancer Inflammation Index in Elderly Patients with Esophageal Cancer Cancer Management and Research esophageal cancer sarcopenia l3 skeletal muscle index survival advanced lung cancer inflammation index. |
| title | Prognostic Significance of the L3 Skeletal Muscle Index and Advanced Lung Cancer Inflammation Index in Elderly Patients with Esophageal Cancer |
| title_full | Prognostic Significance of the L3 Skeletal Muscle Index and Advanced Lung Cancer Inflammation Index in Elderly Patients with Esophageal Cancer |
| title_fullStr | Prognostic Significance of the L3 Skeletal Muscle Index and Advanced Lung Cancer Inflammation Index in Elderly Patients with Esophageal Cancer |
| title_full_unstemmed | Prognostic Significance of the L3 Skeletal Muscle Index and Advanced Lung Cancer Inflammation Index in Elderly Patients with Esophageal Cancer |
| title_short | Prognostic Significance of the L3 Skeletal Muscle Index and Advanced Lung Cancer Inflammation Index in Elderly Patients with Esophageal Cancer |
| title_sort | prognostic significance of the l3 skeletal muscle index and advanced lung cancer inflammation index in elderly patients with esophageal cancer |
| topic | esophageal cancer sarcopenia l3 skeletal muscle index survival advanced lung cancer inflammation index. |
| url | https://www.dovepress.com/prognostic-significance-of-the-l3-skeletal-muscle-index-and-advanced-l-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT tanx prognosticsignificanceofthel3skeletalmuscleindexandadvancedlungcancerinflammationindexinelderlypatientswithesophagealcancer AT pengh prognosticsignificanceofthel3skeletalmuscleindexandadvancedlungcancerinflammationindexinelderlypatientswithesophagealcancer AT gup prognosticsignificanceofthel3skeletalmuscleindexandadvancedlungcancerinflammationindexinelderlypatientswithesophagealcancer AT chenm prognosticsignificanceofthel3skeletalmuscleindexandadvancedlungcancerinflammationindexinelderlypatientswithesophagealcancer AT wangy prognosticsignificanceofthel3skeletalmuscleindexandadvancedlungcancerinflammationindexinelderlypatientswithesophagealcancer |