The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis
Abstract Objective To perform quantitative analysis on the efficacy of using relative cerebral blood flow (rCBF) in arterial spin labeling (ASL), relative cerebral blood volume (rCBV) in dynamic magnetic sensitivity contrast-enhanced magnetic resonance imaging (DSC-MRI), and mean kurtosis (MK) in di...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-020-01643-y |
| _version_ | 1819015933666000896 |
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| author | Jixin Luan Mingzhen Wu Xiaohui Wang Lishan Qiao Guifang Guo Chuanchen Zhang |
| author_facet | Jixin Luan Mingzhen Wu Xiaohui Wang Lishan Qiao Guifang Guo Chuanchen Zhang |
| author_sort | Jixin Luan |
| collection | DOAJ |
| description | Abstract Objective To perform quantitative analysis on the efficacy of using relative cerebral blood flow (rCBF) in arterial spin labeling (ASL), relative cerebral blood volume (rCBV) in dynamic magnetic sensitivity contrast-enhanced magnetic resonance imaging (DSC-MRI), and mean kurtosis (MK) in diffusion kurtosis imaging (DKI) to grade cerebral gliomas. Methods Literature regarding ASL, DSC-MRI, or DKI in cerebral gliomas grading in both English and Chinese were searched from PubMed, Embase, Web of Science, CBM, China National Knowledge Infrastructure (CNKI), and Wanfang Database as of 2019. A meta-analysis was performed to evaluate the efficacy of ASL, DSC-MRI, and DKI in the grading of cerebral gliomas. Result A total of 54 articles (11 in Chinese and 43 in English) were included. Three quantitative parameters in the grading of cerebral gliomas, rCBF in ASL, rCBV in DSC-MRI, and MK in DKI had the pooled sensitivity of 0.88 [95% CI (0.83,0.92)], 0.92 [95% CI (0.83,0.96)], 0.88 [95% CI (0.82,0.92)], and the pooled specificity of 0.91 [95% CI (0.84,0.94)], 0.81 [95% CI (0.73,0.88)], 0.86 [95% CI (0.78,0.91)] respectively. The pooled area under the curve (AUC) were 0.95 [95% CI (0.93,0.97)], 0.91 [95% CI (0.89,0.94)], 0.93 [95% CI (0.91,0.95)] respectively. Conclusion Quantitative parameters rCBF, rCBV and MK have high diagnostic accuracy for preoperative grading of cerebral gliomas. |
| first_indexed | 2024-12-21T02:39:37Z |
| format | Article |
| id | doaj.art-c7996accae6d467e8b19a29ce92fb631 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-21T02:39:37Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-c7996accae6d467e8b19a29ce92fb6312022-12-21T19:18:43ZengBMCRadiation Oncology1748-717X2020-08-0115111510.1186/s13014-020-01643-yThe diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysisJixin Luan0Mingzhen Wu1Xiaohui Wang2Lishan Qiao3Guifang Guo4Chuanchen Zhang5Department of Radiology, Liaocheng People’s Hospital, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Radiology, Liaocheng People’s Hospital, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Science and Education, Liaocheng People’s Hospital, Shandong First Medical University & Shandong Academy of Medical SciencesSchool of Mathematics, Liaocheng UniversityDepartment of Radiology, Liaocheng People’s Hospital, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Radiology, Liaocheng People’s Hospital, Shandong First Medical University & Shandong Academy of Medical SciencesAbstract Objective To perform quantitative analysis on the efficacy of using relative cerebral blood flow (rCBF) in arterial spin labeling (ASL), relative cerebral blood volume (rCBV) in dynamic magnetic sensitivity contrast-enhanced magnetic resonance imaging (DSC-MRI), and mean kurtosis (MK) in diffusion kurtosis imaging (DKI) to grade cerebral gliomas. Methods Literature regarding ASL, DSC-MRI, or DKI in cerebral gliomas grading in both English and Chinese were searched from PubMed, Embase, Web of Science, CBM, China National Knowledge Infrastructure (CNKI), and Wanfang Database as of 2019. A meta-analysis was performed to evaluate the efficacy of ASL, DSC-MRI, and DKI in the grading of cerebral gliomas. Result A total of 54 articles (11 in Chinese and 43 in English) were included. Three quantitative parameters in the grading of cerebral gliomas, rCBF in ASL, rCBV in DSC-MRI, and MK in DKI had the pooled sensitivity of 0.88 [95% CI (0.83,0.92)], 0.92 [95% CI (0.83,0.96)], 0.88 [95% CI (0.82,0.92)], and the pooled specificity of 0.91 [95% CI (0.84,0.94)], 0.81 [95% CI (0.73,0.88)], 0.86 [95% CI (0.78,0.91)] respectively. The pooled area under the curve (AUC) were 0.95 [95% CI (0.93,0.97)], 0.91 [95% CI (0.89,0.94)], 0.93 [95% CI (0.91,0.95)] respectively. Conclusion Quantitative parameters rCBF, rCBV and MK have high diagnostic accuracy for preoperative grading of cerebral gliomas.http://link.springer.com/article/10.1186/s13014-020-01643-yGliomasGradingMRIMeta-analysis |
| spellingShingle | Jixin Luan Mingzhen Wu Xiaohui Wang Lishan Qiao Guifang Guo Chuanchen Zhang The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis Radiation Oncology Gliomas Grading MRI Meta-analysis |
| title | The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis |
| title_full | The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis |
| title_fullStr | The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis |
| title_full_unstemmed | The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis |
| title_short | The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis |
| title_sort | diagnostic value of quantitative analysis of asl dsc mri and dki in the grading of cerebral gliomas a meta analysis |
| topic | Gliomas Grading MRI Meta-analysis |
| url | http://link.springer.com/article/10.1186/s13014-020-01643-y |
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