Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysate
In the previous article, we talked about the use of platelet-rich plasma. One of the promising ways to stimulate the processes of repair and regeneration in the tissues of the damaged organ in different types of pathology is the use of platelet-rich plasma lysate. This part of the literature review...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2022-06-01
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| Series: | Трансплантология (Москва) |
| Subjects: | |
| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/656 |
| _version_ | 1826564571981152256 |
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| author | A. M. Fayn A. Yu. Vaza S. F. Gnetetskiy K. I. Skuratovskaya V. B. Bondarev Yu. A. Bogolyubskiy R. S. Titov A. Yu. Sergeev |
| author_facet | A. M. Fayn A. Yu. Vaza S. F. Gnetetskiy K. I. Skuratovskaya V. B. Bondarev Yu. A. Bogolyubskiy R. S. Titov A. Yu. Sergeev |
| author_sort | A. M. Fayn |
| collection | DOAJ |
| description | In the previous article, we talked about the use of platelet-rich plasma. One of the promising ways to stimulate the processes of repair and regeneration in the tissues of the damaged organ in different types of pathology is the use of platelet-rich plasma lysate. This part of the literature review covers the mechanism of action of platelet-rich plasma lysate, indications and contraindications for its use, describes the results of treatment when platelet-rich plasma lysate is used to stimulate osteogenesis. The preparation technology provides for the removal of all cellular components from the plasma, so it becomes possible to store the obtained graft for a long time. The procedure for the preparation of platelet lysate allows the simultaneous isolation of all growth factors from the cells, since the platelet lysis occurs. Lysate of platelet concentrates can be considered as a preparation that contains a complete set of stimulating growth factors. Under the influence of the lysate, the proliferation of latent osteoblasts is resumed, the signaling pathways of angiogenesis are activated, the secretion of the factors accelerating angiogenesis is stimulated, the differentiation of osteoblasts and the formation of bone tissue are triggered. The aim of this article is to summarize the results of treatment using autologous platelet lysate to improve bone regenerative potential in orthopaedics. In a final article, we shall look at the ways to use autologous red bone marrow. |
| first_indexed | 2024-03-12T04:18:22Z |
| format | Article |
| id | doaj.art-c799924ddda946d48b68d58010647a6f |
| institution | Directory Open Access Journal |
| issn | 2074-0506 2542-0909 |
| language | English |
| last_indexed | 2025-03-14T10:21:59Z |
| publishDate | 2022-06-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj.art-c799924ddda946d48b68d58010647a6f2025-03-02T11:07:35ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092022-06-0114218419410.23873/2074-0506-2022-14-2-184-194514Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysateA. M. Fayn0A. Yu. Vaza1S. F. Gnetetskiy2K. I. Skuratovskaya3V. B. Bondarev4Yu. A. Bogolyubskiy5R. S. Titov6A. Yu. Sergeev7N.V. Sklifosovsky Research Institute for Emergency Medicine; A.I. Yevdokimov Moscow State University of Medicine and DentistryN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency Medicine; A.I. Yevdokimov Moscow State University of Medicine and DentistryN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineIn the previous article, we talked about the use of platelet-rich plasma. One of the promising ways to stimulate the processes of repair and regeneration in the tissues of the damaged organ in different types of pathology is the use of platelet-rich plasma lysate. This part of the literature review covers the mechanism of action of platelet-rich plasma lysate, indications and contraindications for its use, describes the results of treatment when platelet-rich plasma lysate is used to stimulate osteogenesis. The preparation technology provides for the removal of all cellular components from the plasma, so it becomes possible to store the obtained graft for a long time. The procedure for the preparation of platelet lysate allows the simultaneous isolation of all growth factors from the cells, since the platelet lysis occurs. Lysate of platelet concentrates can be considered as a preparation that contains a complete set of stimulating growth factors. Under the influence of the lysate, the proliferation of latent osteoblasts is resumed, the signaling pathways of angiogenesis are activated, the secretion of the factors accelerating angiogenesis is stimulated, the differentiation of osteoblasts and the formation of bone tissue are triggered. The aim of this article is to summarize the results of treatment using autologous platelet lysate to improve bone regenerative potential in orthopaedics. In a final article, we shall look at the ways to use autologous red bone marrow.https://www.jtransplantologiya.ru/jour/article/view/656bone regenerationpseudoarthrosisplatelet-rich plasmagrowth factorsbone graftin |
| spellingShingle | A. M. Fayn A. Yu. Vaza S. F. Gnetetskiy K. I. Skuratovskaya V. B. Bondarev Yu. A. Bogolyubskiy R. S. Titov A. Yu. Sergeev Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysate Трансплантология (Москва) bone regeneration pseudoarthrosis platelet-rich plasma growth factors bone graftin |
| title | Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysate |
| title_full | Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysate |
| title_fullStr | Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysate |
| title_full_unstemmed | Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysate |
| title_short | Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysate |
| title_sort | available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics part 2 use of autologous human platelet lysate |
| topic | bone regeneration pseudoarthrosis platelet-rich plasma growth factors bone graftin |
| url | https://www.jtransplantologiya.ru/jour/article/view/656 |
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