Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2)
KMT2A-AFF1 (MLL-AF4), formed by chromosomal translocation t(4;11), is observed specifically in infant pro-B acute lymphoblastic leukemia, and the main driver of leukemogenesis. In this study, a human induced pluripotent stem cell (hiPSC) line harboring KMT2A-AFF1 (IMSUTi002-A-2), which has the abili...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187350612300171X |
| _version_ | 1827824194394521600 |
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| author | Masayuki Takahashi |
| author_facet | Masayuki Takahashi |
| author_sort | Masayuki Takahashi |
| collection | DOAJ |
| description | KMT2A-AFF1 (MLL-AF4), formed by chromosomal translocation t(4;11), is observed specifically in infant pro-B acute lymphoblastic leukemia, and the main driver of leukemogenesis. In this study, a human induced pluripotent stem cell (hiPSC) line harboring KMT2A-AFF1 (IMSUTi002-A-2), which has the ability to simultaneously induce the doxycycline-inducible expression of KMT2A-AFF1 and EGFP, was established. This hiPSC can be a powerful model for understanding infant leukemia and risk assessment of leukemogenesis. |
| first_indexed | 2024-03-12T02:22:29Z |
| format | Article |
| id | doaj.art-c79ab8ac56f2411fabecd56c5823cb0f |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-12T02:22:29Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-c79ab8ac56f2411fabecd56c5823cb0f2023-09-06T04:50:57ZengElsevierStem Cell Research1873-50612023-09-0171103185Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2)Masayuki Takahashi0Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Chiba, JapanKMT2A-AFF1 (MLL-AF4), formed by chromosomal translocation t(4;11), is observed specifically in infant pro-B acute lymphoblastic leukemia, and the main driver of leukemogenesis. In this study, a human induced pluripotent stem cell (hiPSC) line harboring KMT2A-AFF1 (IMSUTi002-A-2), which has the ability to simultaneously induce the doxycycline-inducible expression of KMT2A-AFF1 and EGFP, was established. This hiPSC can be a powerful model for understanding infant leukemia and risk assessment of leukemogenesis.http://www.sciencedirect.com/science/article/pii/S187350612300171X |
| spellingShingle | Masayuki Takahashi Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2) Stem Cell Research |
| title | Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2) |
| title_full | Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2) |
| title_fullStr | Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2) |
| title_full_unstemmed | Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2) |
| title_short | Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2) |
| title_sort | generation of a human induced pluripotent stem cell line harboring the infant leukemia associated fusion gene kmt2a aff1 imsuti002 a 2 |
| url | http://www.sciencedirect.com/science/article/pii/S187350612300171X |
| work_keys_str_mv | AT masayukitakahashi generationofahumaninducedpluripotentstemcelllineharboringtheinfantleukemiaassociatedfusiongenekmt2aaff1imsuti002a2 |