A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Abstract Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been totally elucidated. Methods Here, to...

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Bibliographic Details
Main Authors: Chao Wu, Zhi-Hong Huang, Zi-Qi Meng, Xiao-Tian Fan, Shan Lu, Ying-Ying Tan, Lei-Ming You, Jia-Qi Huang, Antony Stalin, Pei-Zhi Ye, Zhi-Shan Wu, Jing-Yuan Zhang, Xin-Kui Liu, Wei Zhou, Xiao-Meng Zhang, Jia-Rui Wu
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Chinese Medicine
Subjects:
Compound kushen injection
Pancreatic cancer
WGCNA
Network pharmacology
Online Access:https://doi.org/10.1186/s13020-021-00534-y

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