Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis

Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis

BackgroundAcute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease. Nuclear factor‐κB is a nuclear transcription factor activated post‐ischemia, responsible for the transcription of proinflammatory proteins. The role of nuclear factor‐κB in the renal fibrosis po...

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Bibliographic Details
Main Authors: Florence L. Johnson, Nimesh S. A. Patel, Gareth S. D. Purvis, Fausto Chiazza, Jianmin Chen, Regina Sordi, Guillaume Hache, Viktoria V. Merezhko, Massimo Collino, Muhammed M. Yaqoob, Christoph Thiemermann
Format: Article
Language:English
Published: Wiley 2017-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
acute kidney injury
fibrosis
ischemia
IκB kinase
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.005092

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