Long-Term Antibiotic Prophylaxis in Urology and High Incidence of <i>Clostridioides difficile</i> Infections in Surgical Adult Patients
<i>Clostridioides difficile</i> infections are the main cause of antibiotic-related diarrhea. Most of them come in the form of healthcare-associated <i>Clostridioides difficile</i> infections (HA-CDI). The aim of the study was to analyze HA-CDI epidemiology and the relationsh...
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MDPI AG
2020-05-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/6/810 |
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| author | Estera Jachowicz Marta Wałaszek Grzegorz Sulimka Andrzej Maciejczak Witold Zieńczuk Damian Kołodziej Jacek Karaś Monika Pobiega Jadwiga Wójkowska-Mach |
| author_facet | Estera Jachowicz Marta Wałaszek Grzegorz Sulimka Andrzej Maciejczak Witold Zieńczuk Damian Kołodziej Jacek Karaś Monika Pobiega Jadwiga Wójkowska-Mach |
| author_sort | Estera Jachowicz |
| collection | DOAJ |
| description | <i>Clostridioides difficile</i> infections are the main cause of antibiotic-related diarrhea. Most of them come in the form of healthcare-associated <i>Clostridioides difficile</i> infections (HA-CDI). The aim of the study was to analyze HA-CDI epidemiology and the relationship between antibiotic consumption and CDI epidemiology at St Luke’s Provincial Hospital in Tarnow, Poland. In 2012–2018, surveillance of CDI was carried out in adult surgical wards at St Luke’s Provincial Hospital. The data were collected in accordance with the methodology of the Healthcare-Associated Infections Surveillance Network (HAI-Net), European Centre for Disease Prevention and Control (ECDC), and the ATC/DDD system (Anatomical Therapeutic Chemical Classification System) of the World Health Organization. In total, in the study period, 51 cases of CDI involved CA-CDI (24.5%) and 147 were HA-CDIs (75.5%). The most CA-CDIs were found in the general surgery (32.6%) and urology (17.0%) wards. CA-CDI incidence was 0.7/1000 patients and for HA-CDI it was 2/1000 patients (4.4/10,000 patientdays (pds)). The highest HA-CDI incidence was in the neurosurgical departments (18/10,000 pds) and oncological surgery (8.4/10,000) pds. There was a significant positive correlation between CA-CDI and HA-CDI (correlation of 0.943, <i>p</i> < 0.001) and between the number of patients hospitalized and HA-CDI (correlation of 0.865, <i>p</i> = 0.012). The total antibiotic consumption amounted to 0.7 DDD/10,000 pds; it was the highest in the urology ward (0.84/10,000 pds) and 49.5% of the antibiotics were fluoroquinolones (0.41/10,000 pds). On the basis of regression coefficients, a positive correlation was demonstrated between the use of fluoroquinolones and the HA-CDI incidence rate. Both a high percentage of CDI cases and a high intake of antibiotics were recorded in the urology department. About half of all antibiotics were fluoroquinolones. |
| first_indexed | 2024-03-10T19:32:14Z |
| format | Article |
| id | doaj.art-c7a3e105d1604ac7b70763cc56947210 |
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| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T19:32:14Z |
| publishDate | 2020-05-01 |
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| series | Microorganisms |
| spelling | doaj.art-c7a3e105d1604ac7b70763cc569472102023-11-20T02:03:01ZengMDPI AGMicroorganisms2076-26072020-05-018681010.3390/microorganisms8060810Long-Term Antibiotic Prophylaxis in Urology and High Incidence of <i>Clostridioides difficile</i> Infections in Surgical Adult PatientsEstera Jachowicz0Marta Wałaszek1Grzegorz Sulimka2Andrzej Maciejczak3Witold Zieńczuk4Damian Kołodziej5Jacek Karaś6Monika Pobiega7Jadwiga Wójkowska-Mach8Department of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, 18 Czysta Street, 31-121 Krakow, PolandState Higher Vocational School, St. Luke’s Provincial Hospital, 31-100 Tarnow, PolandSt. Luke’s Provincial Hospital, 31-100 Tarnów, PolandSt. Luke’s Provincial Hospital, 31-100 Tarnów, PolandSt. Luke’s Provincial Hospital, 31-100 Tarnów, PolandSt. Luke’s Provincial Hospital, 31-100 Tarnów, PolandSt. Luke’s Provincial Hospital, 31-100 Tarnów, PolandDepartment of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, 18 Czysta Street, 31-121 Krakow, PolandDepartment of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, 18 Czysta Street, 31-121 Krakow, Poland<i>Clostridioides difficile</i> infections are the main cause of antibiotic-related diarrhea. Most of them come in the form of healthcare-associated <i>Clostridioides difficile</i> infections (HA-CDI). The aim of the study was to analyze HA-CDI epidemiology and the relationship between antibiotic consumption and CDI epidemiology at St Luke’s Provincial Hospital in Tarnow, Poland. In 2012–2018, surveillance of CDI was carried out in adult surgical wards at St Luke’s Provincial Hospital. The data were collected in accordance with the methodology of the Healthcare-Associated Infections Surveillance Network (HAI-Net), European Centre for Disease Prevention and Control (ECDC), and the ATC/DDD system (Anatomical Therapeutic Chemical Classification System) of the World Health Organization. In total, in the study period, 51 cases of CDI involved CA-CDI (24.5%) and 147 were HA-CDIs (75.5%). The most CA-CDIs were found in the general surgery (32.6%) and urology (17.0%) wards. CA-CDI incidence was 0.7/1000 patients and for HA-CDI it was 2/1000 patients (4.4/10,000 patientdays (pds)). The highest HA-CDI incidence was in the neurosurgical departments (18/10,000 pds) and oncological surgery (8.4/10,000) pds. There was a significant positive correlation between CA-CDI and HA-CDI (correlation of 0.943, <i>p</i> < 0.001) and between the number of patients hospitalized and HA-CDI (correlation of 0.865, <i>p</i> = 0.012). The total antibiotic consumption amounted to 0.7 DDD/10,000 pds; it was the highest in the urology ward (0.84/10,000 pds) and 49.5% of the antibiotics were fluoroquinolones (0.41/10,000 pds). On the basis of regression coefficients, a positive correlation was demonstrated between the use of fluoroquinolones and the HA-CDI incidence rate. Both a high percentage of CDI cases and a high intake of antibiotics were recorded in the urology department. About half of all antibiotics were fluoroquinolones.https://www.mdpi.com/2076-2607/8/6/810<i>C. difficile</i>healthcare-associated infectionsperioperative antimicrobial prophylaxisantibiotic consumption |
| spellingShingle | Estera Jachowicz Marta Wałaszek Grzegorz Sulimka Andrzej Maciejczak Witold Zieńczuk Damian Kołodziej Jacek Karaś Monika Pobiega Jadwiga Wójkowska-Mach Long-Term Antibiotic Prophylaxis in Urology and High Incidence of <i>Clostridioides difficile</i> Infections in Surgical Adult Patients Microorganisms <i>C. difficile</i> healthcare-associated infections perioperative antimicrobial prophylaxis antibiotic consumption |
| title | Long-Term Antibiotic Prophylaxis in Urology and High Incidence of <i>Clostridioides difficile</i> Infections in Surgical Adult Patients |
| title_full | Long-Term Antibiotic Prophylaxis in Urology and High Incidence of <i>Clostridioides difficile</i> Infections in Surgical Adult Patients |
| title_fullStr | Long-Term Antibiotic Prophylaxis in Urology and High Incidence of <i>Clostridioides difficile</i> Infections in Surgical Adult Patients |
| title_full_unstemmed | Long-Term Antibiotic Prophylaxis in Urology and High Incidence of <i>Clostridioides difficile</i> Infections in Surgical Adult Patients |
| title_short | Long-Term Antibiotic Prophylaxis in Urology and High Incidence of <i>Clostridioides difficile</i> Infections in Surgical Adult Patients |
| title_sort | long term antibiotic prophylaxis in urology and high incidence of i clostridioides difficile i infections in surgical adult patients |
| topic | <i>C. difficile</i> healthcare-associated infections perioperative antimicrobial prophylaxis antibiotic consumption |
| url | https://www.mdpi.com/2076-2607/8/6/810 |
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