Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua
Abstract One undescribed amide, pipermullesine A, two undescribed isoquinoline alkaloids, pipermullesines B and C, and six undescribed dipeptides, pipermullamides A–F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua. The structures of the undescribed compounds we...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-08-01
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| Series: | Natural Products and Bioprospecting |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13659-018-0180-z |
| _version_ | 1818138999846338560 |
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| author | Meng-Yuan Xia Jun Yang Pan-Hua Zhang Xiao-Nian Li Ji-Feng Luo Chun-Lin Long Yue-Hu Wang |
| author_facet | Meng-Yuan Xia Jun Yang Pan-Hua Zhang Xiao-Nian Li Ji-Feng Luo Chun-Lin Long Yue-Hu Wang |
| author_sort | Meng-Yuan Xia |
| collection | DOAJ |
| description | Abstract One undescribed amide, pipermullesine A, two undescribed isoquinoline alkaloids, pipermullesines B and C, and six undescribed dipeptides, pipermullamides A–F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua. The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data. Furthermore, the structures of pipermullesines A–C were confirmed by single crystal X-ray diffraction analysis. All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin (IIa) or platelet-activating factor (PAF). (-)-Mangochinine, pellitorine, and (2E,4E)-N-isobutyl-2,4-dodecadienamide showed weak inhibitory activity against rabbit platelet aggregation induced by PAF, with IC50 values of 470.3 µg/mL, 614.9 µg/mL, and 579.7 µg/mL, respectively. Graphical Abstract |
| first_indexed | 2024-12-11T10:21:07Z |
| format | Article |
| id | doaj.art-c7a5de3f7c3e4eb4896f5d422c93014a |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-12-11T10:21:07Z |
| publishDate | 2018-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-c7a5de3f7c3e4eb4896f5d422c93014a2022-12-22T01:11:26ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092018-08-018641943010.1007/s13659-018-0180-zAmides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesuaMeng-Yuan Xia0Jun Yang1Pan-Hua Zhang2Xiao-Nian Li3Ji-Feng Luo4Chun-Lin Long5Yue-Hu Wang6Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of SciencesKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of SciencesKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of SciencesCollege of Life and Environmental Sciences, Minzu University of ChinaKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of SciencesAbstract One undescribed amide, pipermullesine A, two undescribed isoquinoline alkaloids, pipermullesines B and C, and six undescribed dipeptides, pipermullamides A–F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua. The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data. Furthermore, the structures of pipermullesines A–C were confirmed by single crystal X-ray diffraction analysis. All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin (IIa) or platelet-activating factor (PAF). (-)-Mangochinine, pellitorine, and (2E,4E)-N-isobutyl-2,4-dodecadienamide showed weak inhibitory activity against rabbit platelet aggregation induced by PAF, with IC50 values of 470.3 µg/mL, 614.9 µg/mL, and 579.7 µg/mL, respectively. Graphical Abstracthttp://link.springer.com/article/10.1007/s13659-018-0180-zPiper mullesuaPiperaceaeAntiplateletAmidesIsoquinoline alkaloids |
| spellingShingle | Meng-Yuan Xia Jun Yang Pan-Hua Zhang Xiao-Nian Li Ji-Feng Luo Chun-Lin Long Yue-Hu Wang Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua Natural Products and Bioprospecting Piper mullesua Piperaceae Antiplatelet Amides Isoquinoline alkaloids |
| title | Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua |
| title_full | Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua |
| title_fullStr | Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua |
| title_full_unstemmed | Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua |
| title_short | Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua |
| title_sort | amides isoquinoline alkaloids and dipeptides from the aerial parts of piper mullesua |
| topic | Piper mullesua Piperaceae Antiplatelet Amides Isoquinoline alkaloids |
| url | http://link.springer.com/article/10.1007/s13659-018-0180-z |
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