Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort
<i>Background and objectives</i>: Chronic obstructive pulmonary disease (COPD) is usually comorbid with other chronic diseases. We aimed to assess the multimorbidity medication patterns and explore if the patterns are similar for phase 1 (P1) and 5-year follow-up phase 2 (P2) in the COPD...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/5/976 |
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| author | Yisha Li Sarah J. Schmiege Heather Anderson Nicole E. Richmond Kendra A. Young John E. Hokanson Stephen I. Rennard Tessa L. Crume Erin Austin Katherine A. Pratte Rebecca Conway Gregory L. Kinney |
| author_facet | Yisha Li Sarah J. Schmiege Heather Anderson Nicole E. Richmond Kendra A. Young John E. Hokanson Stephen I. Rennard Tessa L. Crume Erin Austin Katherine A. Pratte Rebecca Conway Gregory L. Kinney |
| author_sort | Yisha Li |
| collection | DOAJ |
| description | <i>Background and objectives</i>: Chronic obstructive pulmonary disease (COPD) is usually comorbid with other chronic diseases. We aimed to assess the multimorbidity medication patterns and explore if the patterns are similar for phase 1 (P1) and 5-year follow-up phase 2 (P2) in the COPDGene cohort. Materials and Methods: A total of 5564 out of 10,198 smokers from the COPDGene cohort who completed 2 visits, P1 and P2 visits, with complete medication use history were included in the study. We conducted latent class analysis (LCA) among the 27 categories of chronic disease medications, excluding COPD treatments and cancer medications at P1 and P2 separately. The best number of LCA classes was determined through both statistical fit and interpretation of the patterns. <i>Results</i>: We found four classes of medication patterns at both phases. LCA showed that both phases shared similar characteristics in their medication patterns: LC0: low medication; LC1: hypertension (HTN) or cardiovascular disease (CVD)+high cholesterol (Hychol) medication predominant; LC2: HTN/CVD+type 2 diabetes (T2D) +Hychol medication predominant; LC3: Hychol medication predominant. <i>Conclusions</i>: We found similar multimorbidity medication patterns among smokers at P1 and P2 in the COPDGene cohort, which provides an understanding of how multimorbidity medication clustered and how different chronic diseases combine in smokers. |
| first_indexed | 2024-03-11T03:31:40Z |
| format | Article |
| id | doaj.art-c7a91335f7f74368811c173e4ed07567 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T03:31:40Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-c7a91335f7f74368811c173e4ed075672023-11-18T02:23:08ZengMDPI AGMedicina1010-660X1648-91442023-05-0159597610.3390/medicina59050976Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene CohortYisha Li0Sarah J. Schmiege1Heather Anderson2Nicole E. Richmond3Kendra A. Young4John E. Hokanson5Stephen I. Rennard6Tessa L. Crume7Erin Austin8Katherine A. Pratte9Rebecca Conway10Gregory L. Kinney11Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Pulmonary, Critical Care and Sleep Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USAMathematical and Statistical Sciences, University of Colorado Denver, Denver, CO 80204, USADivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO 80206, USADepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA<i>Background and objectives</i>: Chronic obstructive pulmonary disease (COPD) is usually comorbid with other chronic diseases. We aimed to assess the multimorbidity medication patterns and explore if the patterns are similar for phase 1 (P1) and 5-year follow-up phase 2 (P2) in the COPDGene cohort. Materials and Methods: A total of 5564 out of 10,198 smokers from the COPDGene cohort who completed 2 visits, P1 and P2 visits, with complete medication use history were included in the study. We conducted latent class analysis (LCA) among the 27 categories of chronic disease medications, excluding COPD treatments and cancer medications at P1 and P2 separately. The best number of LCA classes was determined through both statistical fit and interpretation of the patterns. <i>Results</i>: We found four classes of medication patterns at both phases. LCA showed that both phases shared similar characteristics in their medication patterns: LC0: low medication; LC1: hypertension (HTN) or cardiovascular disease (CVD)+high cholesterol (Hychol) medication predominant; LC2: HTN/CVD+type 2 diabetes (T2D) +Hychol medication predominant; LC3: Hychol medication predominant. <i>Conclusions</i>: We found similar multimorbidity medication patterns among smokers at P1 and P2 in the COPDGene cohort, which provides an understanding of how multimorbidity medication clustered and how different chronic diseases combine in smokers.https://www.mdpi.com/1648-9144/59/5/976chronic diseasesmedication patternslatent class analysissmoker |
| spellingShingle | Yisha Li Sarah J. Schmiege Heather Anderson Nicole E. Richmond Kendra A. Young John E. Hokanson Stephen I. Rennard Tessa L. Crume Erin Austin Katherine A. Pratte Rebecca Conway Gregory L. Kinney Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort Medicina chronic diseases medication patterns latent class analysis smoker |
| title | Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort |
| title_full | Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort |
| title_fullStr | Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort |
| title_full_unstemmed | Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort |
| title_short | Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort |
| title_sort | longitudinal assessment of multimorbidity medication patterns among smokers in the copdgene cohort |
| topic | chronic diseases medication patterns latent class analysis smoker |
| url | https://www.mdpi.com/1648-9144/59/5/976 |
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