High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
Abstract The study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high‐sucrose (HS), high‐fat (HF), and high‐fat with sucrose (HFHS) for 2...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15635 |
| _version_ | 1797397166753316864 |
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| author | Jéssika Butcovsky Botto Sarter Kobi Amanda Martins Matias Patrícia Vasconcelos Fontana Gasparini Suellem Torezani‐Sales Amanda Rangel Madureira Daniel Sesana da Silva Camila Renata Correa Jéssica Leite Garcia Douglas Haese Breno Valentim Nogueira Arícia Leone Evangelista Monteiro deAssis Ana Paula Lima‐Leopoldo André Soares Leopoldo |
| author_facet | Jéssika Butcovsky Botto Sarter Kobi Amanda Martins Matias Patrícia Vasconcelos Fontana Gasparini Suellem Torezani‐Sales Amanda Rangel Madureira Daniel Sesana da Silva Camila Renata Correa Jéssica Leite Garcia Douglas Haese Breno Valentim Nogueira Arícia Leone Evangelista Monteiro deAssis Ana Paula Lima‐Leopoldo André Soares Leopoldo |
| author_sort | Jéssika Butcovsky Botto Sarter Kobi |
| collection | DOAJ |
| description | Abstract The study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high‐sucrose (HS), high‐fat (HF), and high‐fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation. |
| first_indexed | 2024-03-09T01:06:03Z |
| format | Article |
| id | doaj.art-c7a9199fbec4408082bdab2d4d78b5f6 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-09T01:06:03Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-c7a9199fbec4408082bdab2d4d78b5f62023-12-11T09:20:39ZengWileyPhysiological Reports2051-817X2023-04-01117n/an/a10.14814/phy2.15635High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesityJéssika Butcovsky Botto Sarter Kobi0Amanda Martins Matias1Patrícia Vasconcelos Fontana Gasparini2Suellem Torezani‐Sales3Amanda Rangel Madureira4Daniel Sesana da Silva5Camila Renata Correa6Jéssica Leite Garcia7Douglas Haese8Breno Valentim Nogueira9Arícia Leone Evangelista Monteiro deAssis10Ana Paula Lima‐Leopoldo11André Soares Leopoldo12Postgraduate Program in Nutrition and Health, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilPostgraduate Program in Physiological Science, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilPostgraduate Program in Physical Education, Center of Physical Education and Sports Federal University of Espírito Santo Vitória Espírito Santo BrazilThe Medical School São Paulo State University Botucatu São Paulo BrazilThe Medical School São Paulo State University Botucatu São Paulo BrazilUniversity of Vila Velha Vila Velha Espírito Santo BrazilDepartment of Morphology, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilDepartment of Morphology, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center Federal University of Espírito Santo Vitória Espírito Santo BrazilAbstract The study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high‐sucrose (HS), high‐fat (HF), and high‐fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation.https://doi.org/10.14814/phy2.15635dietsinflammationobesityoxidative stressrats |
| spellingShingle | Jéssika Butcovsky Botto Sarter Kobi Amanda Martins Matias Patrícia Vasconcelos Fontana Gasparini Suellem Torezani‐Sales Amanda Rangel Madureira Daniel Sesana da Silva Camila Renata Correa Jéssica Leite Garcia Douglas Haese Breno Valentim Nogueira Arícia Leone Evangelista Monteiro deAssis Ana Paula Lima‐Leopoldo André Soares Leopoldo High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity Physiological Reports diets inflammation obesity oxidative stress rats |
| title | High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
| title_full | High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
| title_fullStr | High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
| title_full_unstemmed | High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
| title_short | High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
| title_sort | high fat high sucrose and combined high fat high sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
| topic | diets inflammation obesity oxidative stress rats |
| url | https://doi.org/10.14814/phy2.15635 |
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