Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia
Background: Resistance to pharmacotherapy is one of the major challenges in the management of obsessive-compulsive disorder (OCD). OCD being a quite prevalent disorder, this resistance adds to the disability. Different strategies are being employed to counter this resistance, one of them being augme...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-01-01
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| Series: | Indian Journal of Psychological Medicine |
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| Online Access: | http://www.ijpm.info/article.asp?issn=0253-7176;year=2015;volume=37;issue=2;spage=154;epage=158;aulast=Hussain |
| _version_ | 1818589891645145088 |
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| author | Arshad Hussain Mansoor Ahmad Dar Rayees Ahmad Wani Majid Shafi Shah Mohd Muzzaffar Jan Yasir A Malik Rajesh Kumar Chandel Mushtaq Ahmad Margoob |
| author_facet | Arshad Hussain Mansoor Ahmad Dar Rayees Ahmad Wani Majid Shafi Shah Mohd Muzzaffar Jan Yasir A Malik Rajesh Kumar Chandel Mushtaq Ahmad Margoob |
| author_sort | Arshad Hussain |
| collection | DOAJ |
| description | Background: Resistance to pharmacotherapy is one of the major challenges in the management of obsessive-compulsive disorder (OCD). OCD being a quite prevalent disorder, this resistance adds to the disability. Different strategies are being employed to counter this resistance, one of them being augmentation with glutamatergic modulators. Lamotrigine is being used for same since the recent past with mixed results. Objective: The aim was to study the role of lamotrigine augmentation in serotonin reuptake inhibitor (SRI) resistant OCD patients. Methodology and Results: This study was carried by studying the case sheets of SRI resistant cases having already completed the treatment. A total of 22 cases sheets over 2 years met the study criteria with a mean age of mean age of 34.14 years. Over a period of 16 weeks, with a mean lamotrigine dose of 150 mg/day, 20 out of 22 patients had shown a significant response. The mean decrease in Yale-Brown Obsessive Compulsive Scale score was 67.23% with a baseline score of 28.87. There was a similar change on different domains of World Health Organization quality of life (P = 0.00564). Conclusion: Lamotrigine augmentation to on-going treatment with SRIs may be an effective move in case of SRI resistant OCD patients. |
| first_indexed | 2024-12-16T09:47:51Z |
| format | Article |
| id | doaj.art-c7a988e1d7e74cf4b99b757f0d8020b7 |
| institution | Directory Open Access Journal |
| issn | 0253-7176 |
| language | English |
| last_indexed | 2024-12-16T09:47:51Z |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-c7a988e1d7e74cf4b99b757f0d8020b72022-12-21T22:36:08ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762015-01-0137215415810.4103/0253-7176.155613Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South AsiaArshad HussainMansoor Ahmad DarRayees Ahmad WaniMajid Shafi ShahMohd Muzzaffar JanYasir A MalikRajesh Kumar ChandelMushtaq Ahmad MargoobBackground: Resistance to pharmacotherapy is one of the major challenges in the management of obsessive-compulsive disorder (OCD). OCD being a quite prevalent disorder, this resistance adds to the disability. Different strategies are being employed to counter this resistance, one of them being augmentation with glutamatergic modulators. Lamotrigine is being used for same since the recent past with mixed results. Objective: The aim was to study the role of lamotrigine augmentation in serotonin reuptake inhibitor (SRI) resistant OCD patients. Methodology and Results: This study was carried by studying the case sheets of SRI resistant cases having already completed the treatment. A total of 22 cases sheets over 2 years met the study criteria with a mean age of mean age of 34.14 years. Over a period of 16 weeks, with a mean lamotrigine dose of 150 mg/day, 20 out of 22 patients had shown a significant response. The mean decrease in Yale-Brown Obsessive Compulsive Scale score was 67.23% with a baseline score of 28.87. There was a similar change on different domains of World Health Organization quality of life (P = 0.00564). Conclusion: Lamotrigine augmentation to on-going treatment with SRIs may be an effective move in case of SRI resistant OCD patients.http://www.ijpm.info/article.asp?issn=0253-7176;year=2015;volume=37;issue=2;spage=154;epage=158;aulast=HussainAugmentationlamotrigineobsessive-compulsive disorderserotonin reuptake inhibitor resistance |
| spellingShingle | Arshad Hussain Mansoor Ahmad Dar Rayees Ahmad Wani Majid Shafi Shah Mohd Muzzaffar Jan Yasir A Malik Rajesh Kumar Chandel Mushtaq Ahmad Margoob Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia Indian Journal of Psychological Medicine Augmentation lamotrigine obsessive-compulsive disorder serotonin reuptake inhibitor resistance |
| title | Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia |
| title_full | Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia |
| title_fullStr | Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia |
| title_full_unstemmed | Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia |
| title_short | Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia |
| title_sort | role of lamotrigine augmentation in treatment resistant obsessive compulsive disorder a retrospective case review from south asia |
| topic | Augmentation lamotrigine obsessive-compulsive disorder serotonin reuptake inhibitor resistance |
| url | http://www.ijpm.info/article.asp?issn=0253-7176;year=2015;volume=37;issue=2;spage=154;epage=158;aulast=Hussain |
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