Autophagy of pathogens alarms the immune system and participates in its effector functions
Macroautophagy is a main catabolic pathway of eukaryotic cells, delivering cytoplasmic constituents for lysosomal degradation. Originally described as a starvation response, it has now been realised that macroautophagy supports many aspects of innate and adaptive immunity by facilitating innate pa...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2011-05-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/1283 |
| _version_ | 1826997275893694464 |
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| author | S Romao C Münz |
| author_facet | S Romao C Münz |
| author_sort | S Romao |
| collection | DOAJ |
| description |
Macroautophagy is a main catabolic pathway of eukaryotic cells, delivering cytoplasmic constituents for lysosomal degradation. Originally described as a starvation response, it has now been realised that macroautophagy supports many aspects of innate and adaptive immunity by facilitating innate pathogen detection and antigen presentation, as well as pathogen clearance and lymphocyte expansion. In the first half of this review, we summarise new insights into substrate selection and macroautophagic support of vesicular transport pathways, which underlie macroautophagic regulation of afferent and efferent immunity to pathogens, as outlined in the second half of the review. Applying this increased mechanistic understanding to infectious disease settings should allow us to identify further pathways for pathogen restriction, which can be explored for therapeutic manipulations of macro-autophagy.
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| first_indexed | 2024-04-12T00:20:36Z |
| format | Article |
| id | doaj.art-c7a9d33935d347d3b4e9882503657adb |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2025-02-18T09:58:29Z |
| publishDate | 2011-05-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-c7a9d33935d347d3b4e9882503657adb2024-11-02T08:54:55ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972011-05-01141192010.4414/smw.2011.13198Autophagy of pathogens alarms the immune system and participates in its effector functionsS RomaoC Münz Macroautophagy is a main catabolic pathway of eukaryotic cells, delivering cytoplasmic constituents for lysosomal degradation. Originally described as a starvation response, it has now been realised that macroautophagy supports many aspects of innate and adaptive immunity by facilitating innate pathogen detection and antigen presentation, as well as pathogen clearance and lymphocyte expansion. In the first half of this review, we summarise new insights into substrate selection and macroautophagic support of vesicular transport pathways, which underlie macroautophagic regulation of afferent and efferent immunity to pathogens, as outlined in the second half of the review. Applying this increased mechanistic understanding to infectious disease settings should allow us to identify further pathways for pathogen restriction, which can be explored for therapeutic manipulations of macro-autophagy. https://www.smw.ch/index.php/smw/article/view/1283cross-presentationendocytosisexocytosismacroautophagyMHC class II presentationsubstrate selection |
| spellingShingle | S Romao C Münz Autophagy of pathogens alarms the immune system and participates in its effector functions Swiss Medical Weekly cross-presentation endocytosis exocytosis macroautophagy MHC class II presentation substrate selection |
| title | Autophagy of pathogens alarms the immune system and participates in its effector functions |
| title_full | Autophagy of pathogens alarms the immune system and participates in its effector functions |
| title_fullStr | Autophagy of pathogens alarms the immune system and participates in its effector functions |
| title_full_unstemmed | Autophagy of pathogens alarms the immune system and participates in its effector functions |
| title_short | Autophagy of pathogens alarms the immune system and participates in its effector functions |
| title_sort | autophagy of pathogens alarms the immune system and participates in its effector functions |
| topic | cross-presentation endocytosis exocytosis macroautophagy MHC class II presentation substrate selection |
| url | https://www.smw.ch/index.php/smw/article/view/1283 |
| work_keys_str_mv | AT sromao autophagyofpathogensalarmstheimmunesystemandparticipatesinitseffectorfunctions AT cmunz autophagyofpathogensalarmstheimmunesystemandparticipatesinitseffectorfunctions |