Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy
Disturbance in microbiota affects the mucosal immune response, and it is gradually recognized to be associated with the Immunoglobin A nephropathy (IgAN). This study aims to explore the potential roles of oral microbiota in disease pathogenesis. Saliva samples were collected from 31 patients with Ig...
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| Format: | Article |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.652837/full |
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| author | Jia-Wei He Xu-Jie Zhou Ping Hou Yan-Na Wang Ting Gan Yang Li Yang Liu Li-Jun Liu Su-Fang Shi Li Zhu Ji-Cheng Lv Hong Zhang |
| author_facet | Jia-Wei He Xu-Jie Zhou Ping Hou Yan-Na Wang Ting Gan Yang Li Yang Liu Li-Jun Liu Su-Fang Shi Li Zhu Ji-Cheng Lv Hong Zhang |
| author_sort | Jia-Wei He |
| collection | DOAJ |
| description | Disturbance in microbiota affects the mucosal immune response, and it is gradually recognized to be associated with the Immunoglobin A nephropathy (IgAN). This study aims to explore the potential roles of oral microbiota in disease pathogenesis. Saliva samples were collected from 31 patients with IgAN and 30 controls for 16S rRNA gene sequencing. The evenness, diversity, and composition of oral microbiota were analyzed. Moreover, sub-phenotype association analysis was conducted. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database was used to investigate microbiota functions. Compared to healthy controls, microbial diversity tended to decrease in IgAN, and the microbial profiles were remarkably distinguished. The relative abundance of Capnocytophaga and SR1_genera_incertae_sedis were enriched, whereas 17 genera, such as Rothia, were significantly reduced in IgAN. Variable importance in projection scores showed that 12 genera, including Capnocytophaga, Rothia, and Haemophilus, could discriminate between the two groups. In the sub-phenotype correlation analysis, the relative abundance of Capnocytophaga and Haemophilus was positively associated with levels of proteinuria and serum IgA, respectively. Further metabolic pathway analysis showed 7 predictive functional profiles, including glycosphingolipid biosynthesis, oxidative phosphorylation, and N-glycan biosynthesis were enriched in IgAN. In conclusion, disturbance in oral microbiota was observed to be associated with IgAN and its sub-phenotypes, which may shed novel insights into disease pathogenesis from a microbiome perspective. |
| first_indexed | 2024-12-21T14:57:20Z |
| format | Article |
| id | doaj.art-c7aa435182154b29adc0128c52fa60be |
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| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-21T14:57:20Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-c7aa435182154b29adc0128c52fa60be2022-12-21T18:59:43ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-04-011110.3389/fcimb.2021.652837652837Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A NephropathyJia-Wei HeXu-Jie ZhouPing HouYan-Na WangTing GanYang LiYang LiuLi-Jun LiuSu-Fang ShiLi ZhuJi-Cheng LvHong ZhangDisturbance in microbiota affects the mucosal immune response, and it is gradually recognized to be associated with the Immunoglobin A nephropathy (IgAN). This study aims to explore the potential roles of oral microbiota in disease pathogenesis. Saliva samples were collected from 31 patients with IgAN and 30 controls for 16S rRNA gene sequencing. The evenness, diversity, and composition of oral microbiota were analyzed. Moreover, sub-phenotype association analysis was conducted. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database was used to investigate microbiota functions. Compared to healthy controls, microbial diversity tended to decrease in IgAN, and the microbial profiles were remarkably distinguished. The relative abundance of Capnocytophaga and SR1_genera_incertae_sedis were enriched, whereas 17 genera, such as Rothia, were significantly reduced in IgAN. Variable importance in projection scores showed that 12 genera, including Capnocytophaga, Rothia, and Haemophilus, could discriminate between the two groups. In the sub-phenotype correlation analysis, the relative abundance of Capnocytophaga and Haemophilus was positively associated with levels of proteinuria and serum IgA, respectively. Further metabolic pathway analysis showed 7 predictive functional profiles, including glycosphingolipid biosynthesis, oxidative phosphorylation, and N-glycan biosynthesis were enriched in IgAN. In conclusion, disturbance in oral microbiota was observed to be associated with IgAN and its sub-phenotypes, which may shed novel insights into disease pathogenesis from a microbiome perspective.https://www.frontiersin.org/articles/10.3389/fcimb.2021.652837/fullIgA nephropathyoral microbiotapathogenesisCapnocytophagaRothiaHaemophilus |
| spellingShingle | Jia-Wei He Xu-Jie Zhou Ping Hou Yan-Na Wang Ting Gan Yang Li Yang Liu Li-Jun Liu Su-Fang Shi Li Zhu Ji-Cheng Lv Hong Zhang Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy Frontiers in Cellular and Infection Microbiology IgA nephropathy oral microbiota pathogenesis Capnocytophaga Rothia Haemophilus |
| title | Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy |
| title_full | Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy |
| title_fullStr | Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy |
| title_full_unstemmed | Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy |
| title_short | Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy |
| title_sort | potential roles of oral microbiota in the pathogenesis of immunoglobin a nephropathy |
| topic | IgA nephropathy oral microbiota pathogenesis Capnocytophaga Rothia Haemophilus |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.652837/full |
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