From discovery to licensure, the Adjuvant System story
Adjuvants are substances added to vaccines to improve their immunogenicity. Used for more than 80 years, aluminum, the first adjuvant in human vaccines, proved insufficient to develop vaccines that could protect against new challenging pathogens such as HIV and malaria. New adjuvants and new combina...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-01-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2016.1225635 |
| _version_ | 1797674574938112000 |
|---|---|
| author | Nathalie Garçon Alberta Di Pasquale |
| author_facet | Nathalie Garçon Alberta Di Pasquale |
| author_sort | Nathalie Garçon |
| collection | DOAJ |
| description | Adjuvants are substances added to vaccines to improve their immunogenicity. Used for more than 80 years, aluminum, the first adjuvant in human vaccines, proved insufficient to develop vaccines that could protect against new challenging pathogens such as HIV and malaria. New adjuvants and new combinations of adjuvants (Adjuvant Systems) have opened the door to the delivery of improved and new vaccines against re-emerging and difficult pathogens. Adjuvant Systems concept started through serendipity. The access to new developments in technology, microbiology and immunology have been instrumental for the dicephering of what they do and how they do it. This knowledge opens the door to more rational vaccine design with implications for developing new and better vaccines. |
| first_indexed | 2024-03-11T22:02:02Z |
| format | Article |
| id | doaj.art-c7abb8a8e65141699ea9a290584c342f |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:02:02Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-c7abb8a8e65141699ea9a290584c342f2023-09-25T11:00:53ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-01-01131193310.1080/21645515.2016.12256351225635From discovery to licensure, the Adjuvant System storyNathalie Garçon0Alberta Di Pasquale1BioasterGSK VaccinesAdjuvants are substances added to vaccines to improve their immunogenicity. Used for more than 80 years, aluminum, the first adjuvant in human vaccines, proved insufficient to develop vaccines that could protect against new challenging pathogens such as HIV and malaria. New adjuvants and new combinations of adjuvants (Adjuvant Systems) have opened the door to the delivery of improved and new vaccines against re-emerging and difficult pathogens. Adjuvant Systems concept started through serendipity. The access to new developments in technology, microbiology and immunology have been instrumental for the dicephering of what they do and how they do it. This knowledge opens the door to more rational vaccine design with implications for developing new and better vaccines.http://dx.doi.org/10.1080/21645515.2016.1225635adaptive immune responseadjuvanted vaccineadjuvantadjuvant systeminnate immune responsevaccine development |
| spellingShingle | Nathalie Garçon Alberta Di Pasquale From discovery to licensure, the Adjuvant System story Human Vaccines & Immunotherapeutics adaptive immune response adjuvanted vaccine adjuvant adjuvant system innate immune response vaccine development |
| title | From discovery to licensure, the Adjuvant System story |
| title_full | From discovery to licensure, the Adjuvant System story |
| title_fullStr | From discovery to licensure, the Adjuvant System story |
| title_full_unstemmed | From discovery to licensure, the Adjuvant System story |
| title_short | From discovery to licensure, the Adjuvant System story |
| title_sort | from discovery to licensure the adjuvant system story |
| topic | adaptive immune response adjuvanted vaccine adjuvant adjuvant system innate immune response vaccine development |
| url | http://dx.doi.org/10.1080/21645515.2016.1225635 |
| work_keys_str_mv | AT nathaliegarcon fromdiscoverytolicensuretheadjuvantsystemstory AT albertadipasquale fromdiscoverytolicensuretheadjuvantsystemstory |