A Mild and Efficient Method for the Syntheses and Regioselective Ring-Opening of Aziridines

A Mild and Efficient Method for the Syntheses and Regioselective Ring-Opening of Aziridines

Abstract We have developed a new synthetic method for the synthesis of aziridines using Chloramine-T as an effective reagent in the presence of NH2OH·HCl and NaIO4. We found that the same combination of NH2OH·HCl and NaIO4 is also very effective for nucleophilic ring opening of aziridines.

Bibliographic Details
Main Authors: Nirnita Chakraborty Ghosal, Sachinta Mahato, Rana Chatterjee, Sougata Santra, Grigory V. Zyryanov, Adinath Majee
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2017-03-01
Series:SynOpen
Subjects:
aziridines
difunctionalization
aminoiodide
in situ generated iodine
room temperature
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588809

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588809

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