Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series
Background Atypical fibroxanthomas (AFX) are rare malignant cutaneous neoplasms. Unfortunately, limited clinicopathologic and outcomes data on this cancer exists. Objective We report the clinical, pathologic, and treatment characteristics, as well as oncologic outcomes in this single-institution ret...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-01-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748231155699 |
| _version_ | 1827959287542972416 |
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| author | Erin McClure BS Michael J Carr MD, MS Ayushi Patel BS Syed Mahrukh Hussnain Naqvi MD, MPH Youngchul Kim PhD Michael Harrington MD Wayne Cruse MD Ricardo J Gonzalez MD Vernon K Sondak MD Amod A Sarnaik MD Jane L Messina MD Jonathan S Zager MD |
| author_facet | Erin McClure BS Michael J Carr MD, MS Ayushi Patel BS Syed Mahrukh Hussnain Naqvi MD, MPH Youngchul Kim PhD Michael Harrington MD Wayne Cruse MD Ricardo J Gonzalez MD Vernon K Sondak MD Amod A Sarnaik MD Jane L Messina MD Jonathan S Zager MD |
| author_sort | Erin McClure BS |
| collection | DOAJ |
| description | Background Atypical fibroxanthomas (AFX) are rare malignant cutaneous neoplasms. Unfortunately, limited clinicopathologic and outcomes data on this cancer exists. Objective We report the clinical, pathologic, and treatment characteristics, as well as oncologic outcomes in this single-institution retrospective analysis. Methods This retrospective cohort study compiled clinical, pathologic, treatment, and outcome data for all patients with AFX on definitive excision diagnosed, evaluated, and treated primarily by surgical resection at a single institution between 2000-2020. Descriptive statistics evaluated clinical and pathologic characteristics. Kaplan-Meier method and Cox proportional-hazards models were used to evaluate overall survival and recurrence-free survival. Results 78 patients with AFX were identified. The majority were elderly, immunocompetent, Caucasian men. 85% of tumors were located on the head and neck. 63% of patients were correctly diagnosed only after complete resection of the index lesion. The median surgical margin was 1.0 cm. Overall, only 1.3% (1/78) of patients developed a local recurrence (RFS). No patients died of disease. Conclusion This study suggests that resection margins of 1 cm achieve excellent local control with close to 99% RFS and 100% disease-specific survival. |
| first_indexed | 2024-04-09T15:48:52Z |
| format | Article |
| id | doaj.art-c7abe111593d48f8891c7567835fa5eb |
| institution | Directory Open Access Journal |
| issn | 1526-2359 |
| language | English |
| last_indexed | 2024-04-09T15:48:52Z |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-c7abe111593d48f8891c7567835fa5eb2023-04-26T13:33:33ZengSAGE PublishingCancer Control1526-23592023-01-013010.1177/10732748231155699Atypical Fibroxanthoma: Outcomes from a Large Single Institution SeriesErin McClure BSMichael J Carr MD, MSAyushi Patel BSSyed Mahrukh Hussnain Naqvi MD, MPHYoungchul Kim PhDMichael Harrington MDWayne Cruse MDRicardo J Gonzalez MDVernon K Sondak MDAmod A Sarnaik MDJane L Messina MDJonathan S Zager MDBackground Atypical fibroxanthomas (AFX) are rare malignant cutaneous neoplasms. Unfortunately, limited clinicopathologic and outcomes data on this cancer exists. Objective We report the clinical, pathologic, and treatment characteristics, as well as oncologic outcomes in this single-institution retrospective analysis. Methods This retrospective cohort study compiled clinical, pathologic, treatment, and outcome data for all patients with AFX on definitive excision diagnosed, evaluated, and treated primarily by surgical resection at a single institution between 2000-2020. Descriptive statistics evaluated clinical and pathologic characteristics. Kaplan-Meier method and Cox proportional-hazards models were used to evaluate overall survival and recurrence-free survival. Results 78 patients with AFX were identified. The majority were elderly, immunocompetent, Caucasian men. 85% of tumors were located on the head and neck. 63% of patients were correctly diagnosed only after complete resection of the index lesion. The median surgical margin was 1.0 cm. Overall, only 1.3% (1/78) of patients developed a local recurrence (RFS). No patients died of disease. Conclusion This study suggests that resection margins of 1 cm achieve excellent local control with close to 99% RFS and 100% disease-specific survival.https://doi.org/10.1177/10732748231155699 |
| spellingShingle | Erin McClure BS Michael J Carr MD, MS Ayushi Patel BS Syed Mahrukh Hussnain Naqvi MD, MPH Youngchul Kim PhD Michael Harrington MD Wayne Cruse MD Ricardo J Gonzalez MD Vernon K Sondak MD Amod A Sarnaik MD Jane L Messina MD Jonathan S Zager MD Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series Cancer Control |
| title | Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series |
| title_full | Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series |
| title_fullStr | Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series |
| title_full_unstemmed | Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series |
| title_short | Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series |
| title_sort | atypical fibroxanthoma outcomes from a large single institution series |
| url | https://doi.org/10.1177/10732748231155699 |
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