Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients
Objective To measure the cranial volume differences from 15 different parts in the follow-up of relapsing-remitting multiple sclerosis (RRMS) patients and correlate them with clinical parameters. Methods Forty-seven patients with RRMS were included in the study. Patients were grouped into...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2023-02-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761492 |
| _version_ | 1797833229252689920 |
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| author | Neslihan Eskut Ali Murat Koc Asli Koskderelioglu Ismail Dilek Mustafa Agah Tekindal |
| author_facet | Neslihan Eskut Ali Murat Koc Asli Koskderelioglu Ismail Dilek Mustafa Agah Tekindal |
| author_sort | Neslihan Eskut |
| collection | DOAJ |
| description | Objective To measure the cranial volume differences from 15 different parts in the follow-up of relapsing-remitting multiple sclerosis (RRMS) patients and correlate them with clinical parameters.
Methods Forty-seven patients with RRMS were included in the study. Patients were grouped into two categories; low Expanded Disability Status Scale (EDSS) (< 3; group 1), and moderate-high EDSS (≥ 3; group 2). Patients were evaluated with Beck Depression Inventory (BDI), Montreal Cognitive Assessment (MOCA), Symbol Digit Modalities Test (SDMT), Fatigue Severity Scale (FSS), and calculated Annualized Relapse Rate (ARR) scores. Magnetic resonance imaging (MRI) was performed with a 1.5T MRI device (Magnetom AERA, Siemens, Erlangen, Germany) twice in a 1-year period. Volumetric analysis was performed by a free, automated, online MRI brain volumetry software. The differences in volumetric values between the two MRI scans were calculated and correlated with the demographic and clinical parameters of the patients.
Results The number of attacks, disease duration, BDI, and FSS scores were higher in group 2; SDMT was higher in group 1. As expected, volumetric analyses have shown volume loss in total cerebral white matter in follow-up patients (p < 0.001). In addition, putaminal volume loss was related to a higher number of attacks. Besides, a negative relation between FSS with total amygdala volumes, a link between atrophy of globus pallidus and ARR, and BDI scores was found with the aid of network analysis.
Conclusions Apart from a visual demonstration of volume loss, cranial MRI with volumetric analysis has a great potential for revealing covert links between segmental volume changes and clinical parameters. |
| first_indexed | 2024-04-09T14:21:01Z |
| format | Article |
| id | doaj.art-c7ad70deed4748c7bd5b92367fa5ac6f |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-04-09T14:21:01Z |
| publishDate | 2023-02-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-c7ad70deed4748c7bd5b92367fa5ac6f2023-05-05T00:41:07ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272023-02-01810216417210.1055/s-0043-1761492Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patientsNeslihan Eskut0Ali Murat Koc1Asli Koskderelioglu2Ismail Dilek3Mustafa Agah Tekindal4University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Department of Neurology, Izmir, Turkey.Izmir Katip Celebi University, Ataturk Education and Research Hospital, Department of Radiology, Izmir, Turkey.University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Department of Neurology, Izmir, Turkey.University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Department of Radiology, Izmir, Turkey.Izmir Katip Celebi University, Department of Biostatistics, Izmir, Turkey.Objective To measure the cranial volume differences from 15 different parts in the follow-up of relapsing-remitting multiple sclerosis (RRMS) patients and correlate them with clinical parameters. Methods Forty-seven patients with RRMS were included in the study. Patients were grouped into two categories; low Expanded Disability Status Scale (EDSS) (< 3; group 1), and moderate-high EDSS (≥ 3; group 2). Patients were evaluated with Beck Depression Inventory (BDI), Montreal Cognitive Assessment (MOCA), Symbol Digit Modalities Test (SDMT), Fatigue Severity Scale (FSS), and calculated Annualized Relapse Rate (ARR) scores. Magnetic resonance imaging (MRI) was performed with a 1.5T MRI device (Magnetom AERA, Siemens, Erlangen, Germany) twice in a 1-year period. Volumetric analysis was performed by a free, automated, online MRI brain volumetry software. The differences in volumetric values between the two MRI scans were calculated and correlated with the demographic and clinical parameters of the patients. Results The number of attacks, disease duration, BDI, and FSS scores were higher in group 2; SDMT was higher in group 1. As expected, volumetric analyses have shown volume loss in total cerebral white matter in follow-up patients (p < 0.001). In addition, putaminal volume loss was related to a higher number of attacks. Besides, a negative relation between FSS with total amygdala volumes, a link between atrophy of globus pallidus and ARR, and BDI scores was found with the aid of network analysis. Conclusions Apart from a visual demonstration of volume loss, cranial MRI with volumetric analysis has a great potential for revealing covert links between segmental volume changes and clinical parameters.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761492multiple sclerosismagnetic resonance imagingsocial network analysisatrophy |
| spellingShingle | Neslihan Eskut Ali Murat Koc Asli Koskderelioglu Ismail Dilek Mustafa Agah Tekindal Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients Arquivos de Neuro-Psiquiatria multiple sclerosis magnetic resonance imaging social network analysis atrophy |
| title | Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients |
| title_full | Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients |
| title_fullStr | Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients |
| title_full_unstemmed | Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients |
| title_short | Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients |
| title_sort | correlation of brain segmental volume changes with clinical parameters a longitudinal study in multiple sclerosis patients |
| topic | multiple sclerosis magnetic resonance imaging social network analysis atrophy |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761492 |
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