A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement
We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium w...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048922000309 |
| _version_ | 1818536400826400768 |
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| author | Labrini Papanastasiou Nikitas Skarakis Maria Vardaka Anastasia Dimitriadi Pinelopi Lampropoulou Anastasia Perpinia Eleftherios Vidalakis Theodosia Choreftaki Theodoros Marinakis Theodora Kounadi Ioannis-Anastasios Vatalas Eurydiki Michalis |
| author_facet | Labrini Papanastasiou Nikitas Skarakis Maria Vardaka Anastasia Dimitriadi Pinelopi Lampropoulou Anastasia Perpinia Eleftherios Vidalakis Theodosia Choreftaki Theodoros Marinakis Theodora Kounadi Ioannis-Anastasios Vatalas Eurydiki Michalis |
| author_sort | Labrini Papanastasiou |
| collection | DOAJ |
| description | We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium wall. An adrenal biopsy revealed the presence of a DLBCL, with triple expression of bcl2, bcl6, C-MYC(+70%). Following six cycles of systemic immunochemotherapy with R-DA-EPOCH, and high methotrexate dose for CNS prophylaxis a marked decrease of lymphoma infiltration was observed. The selection of the appropriate treatment modality can lead to profound response and improve patient's outcome. |
| first_indexed | 2024-12-11T18:37:28Z |
| format | Article |
| id | doaj.art-c7ad88ba49a242c2bbc17ea803de39ea |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-12-11T18:37:28Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-c7ad88ba49a242c2bbc17ea803de39ea2022-12-22T00:54:43ZengElsevierLeukemia Research Reports2213-04892022-01-0117100318A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvementLabrini Papanastasiou0Nikitas Skarakis1Maria Vardaka2Anastasia Dimitriadi3Pinelopi Lampropoulou4Anastasia Perpinia5Eleftherios Vidalakis6Theodosia Choreftaki7Theodoros Marinakis8Theodora Kounadi9Ioannis-Anastasios Vatalas10Eurydiki Michalis11Unit of Endocrinology and Diabetes Center, General Hospital of Athens ''G. Gennimatas'', Athens, Greece; Corresponding author.Unit of Endocrinology and Diabetes Center, General Hospital of Athens ''G. Gennimatas'', Athens, GreeceDepartment of Hematology, General Hospital of Athens 'G Gennimatas', Athens, GreeceDepartment of Pathology, General Hospital of Athens ''G. Gennimatas'', Athens, GreeceDepartment of Radiology, General Hospital of Athens 'G Gennimatas', Athens, GreeceDepartment of Cardiology, General Hospital of Athens 'G Gennimatas', Athens, GreeceMetropolitan General Hospital, Athens, GreeceDepartment of Pathology, General Hospital of Athens ''G. Gennimatas'', Athens, GreeceDepartment of Hematology, General Hospital of Athens 'G Gennimatas', Athens, GreeceUnit of Endocrinology and Diabetes Center, General Hospital of Athens ''G. Gennimatas'', Athens, GreeceMutual Health Fund of National Bank of Greece Personnel (TYPET), Athens, GreeceDepartment of Hematology, General Hospital of Athens 'G Gennimatas', Athens, GreeceWe report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium wall. An adrenal biopsy revealed the presence of a DLBCL, with triple expression of bcl2, bcl6, C-MYC(+70%). Following six cycles of systemic immunochemotherapy with R-DA-EPOCH, and high methotrexate dose for CNS prophylaxis a marked decrease of lymphoma infiltration was observed. The selection of the appropriate treatment modality can lead to profound response and improve patient's outcome.http://www.sciencedirect.com/science/article/pii/S2213048922000309Non-hodgkin's lymphomaCardiac lymphomaAdrenal lymphomaDiffuse large b-cell non-hodgkin lymphoma |
| spellingShingle | Labrini Papanastasiou Nikitas Skarakis Maria Vardaka Anastasia Dimitriadi Pinelopi Lampropoulou Anastasia Perpinia Eleftherios Vidalakis Theodosia Choreftaki Theodoros Marinakis Theodora Kounadi Ioannis-Anastasios Vatalas Eurydiki Michalis A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement Leukemia Research Reports Non-hodgkin's lymphoma Cardiac lymphoma Adrenal lymphoma Diffuse large b-cell non-hodgkin lymphoma |
| title | A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement |
| title_full | A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement |
| title_fullStr | A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement |
| title_full_unstemmed | A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement |
| title_short | A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement |
| title_sort | very rare case of extranodal b cell non hodgkin lymphoma presenting with adrenal and heart involvement |
| topic | Non-hodgkin's lymphoma Cardiac lymphoma Adrenal lymphoma Diffuse large b-cell non-hodgkin lymphoma |
| url | http://www.sciencedirect.com/science/article/pii/S2213048922000309 |
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