AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension

AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension

Hypoxic pulmonary hypertension (HPH) is characterized by sustained elevation of pulmonary artery pressure produced by vasoconstriction and hyperproliferative remodeling of the pulmonary artery and subsequent right ventricular hypertrophy (RVH). The search for therapeutic targets for cardiovascular p...

Full description

Bibliographic Details
Main Authors:	Karen Flores, Patricia Siques, Julio Brito, Silvia M. Arribas
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	International Journal of Molecular Sciences
Subjects:	AMPK hypoxic pulmonary hypertension high altitude cardioprotection
Online Access:	https://www.mdpi.com/1422-0067/23/11/6205

Similar Items

AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
by: A. Mark Evans, et al.
Published: (2020-05-01)

Thin Air, Thick Vessels: Historical and Current Perspectives on Hypoxic Pulmonary Hypertension
by: Jason M. Young, et al.
Published: (2019-05-01)

Inflammation in Pulmonary Hypertension and Edema Induced by Hypobaric Hypoxia Exposure
by: Samia El Alam, et al.
Published: (2022-10-01)

Hpgd affects the progression of hypoxic pulmonary hypertension by regulating vascular remodeling
by: Meng He, et al.
Published: (2023-04-01)

Research progress of endoplasmic reticulum stress of hypoxic pulmonary hypertension
by: LIU Xingxing, WANG Weiwei, YUAN Haoxin
Published: (2023-05-01)

Mitochondria in hypoxic pulmonary hypertension, roles and the potential targets
by: Yumei Geng, et al.
Published: (2023-08-01)

Fit for high altitude: are hypoxic challenge tests useful?
by: Matthys Heinrich
Published: (2011-02-01)

Bibliometric and visual analysis of hypoxic pulmonary hypertension from 2013 to 2022
by: Wei Yang, et al.
Published: (2023-11-01)

DNA-PKcs participated in hypoxic pulmonary hypertension
by: Ying-ying Liu, et al.
Published: (2022-09-01)

Oxidative Stress and Diseases Associated with High-Altitude Exposure
by: Eduardo Pena, et al.
Published: (2022-01-01)

Induction of Glutathione Synthesis Provides Cardioprotection Regulating NO, AMPK and PPARa Signaling in Ischemic Rat Hearts
by: Yulia V. Goshovska, et al.
Published: (2021-06-01)

Contribution of Hypoxic Exercise Testing to Predict High-Altitude Pathology: A Systematic Review
by: Thomas Georges, et al.
Published: (2022-03-01)

Association of Genes of the NO Pathway with Altitude Disease and Hypoxic Pulmonary Hypertension
by: Juliane Hannemann, et al.
Published: (2021-12-01)

Tom70-regulated mitochondrial biogenesis via TFAM improves hypoxia-induced dysfunction of pulmonary vascular endothelial cells and alleviates hypoxic pulmonary hypertension
by: Lei Ma, et al.
Published: (2023-12-01)

A novel clinical prediction scoring system of high-altitude pulmonary hypertension
by: Yanxi Zeng, et al.
Published: (2024-01-01)

Efficacy and Safety of Intermittent Hypoxic Training in the Prevention of Acute Hypoxic Injury
by: HUANG Dan, ZHANG Qihan, SONG Ge, WANG Qing, LI Yu, JI Xunming, WANG Yuan
Published: (2023-10-01)

Effects of Zinc on the Right Cardiovascular Circuit in Long-Term Hypobaric Hypoxia in Wistar Rats
by: Karem Arriaza, et al.
Published: (2023-05-01)

Omentin-1 ameliorates pulmonary arterial hypertension by inhibiting endoplasmic reticulum stress through AMPKα signaling
by: Xinyu Deng, et al.
Published: (2024-12-01)

Protective effects of resveratrol and SR1001 on hypoxia-induced pulmonary hypertension in rats
by: Cheng Li, et al.
Published: (2020-08-01)

Canagliflozin inhibits PASMCs proliferation via regulating SGLT1/AMPK signaling and attenuates artery remodeling in MCT-induced pulmonary arterial hypertension
by: Xiaojun Chen, et al.
Published: (2024-05-01)

Clinical characteristics and predictors of pulmonary hypertension in chronic obstructive pulmonary disease at different altitudes
by: Lixia Wang, et al.
Published: (2023-04-01)

Cardiorespiratory Adaptation to Short-Term Exposure to Altitude vs. Normobaric Hypoxia in Patients with Pulmonary Hypertension
by: Simon R. Schneider, et al.
Published: (2022-05-01)

New Insights into Pulmonary Hypertension: A Role for Connexin-Mediated Signalling
by: Myo Htet, et al.
Published: (2021-12-01)

Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs
by: Cristian R. Astorga, et al.
Published: (2018-03-01)

The emerging roles of SUMOylation in pulmonary diseases
by: Xuyang Zheng, et al.
Published: (2023-09-01)

EFFICACY OF INTERMITTENT NORMOBARIC HYPOXIC TRAINING IN THE TREATMENT OF ARTERIAL HYPERTENSION ASSESSED BY 24-HOUR BLOOD PRESSURE MONITORING
by: I A Velizhanina, et al.
Published: (2017-12-01)

Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level
by: Nick P. Talbot, et al.
Published: (2024-02-01)

Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension
by: Yi Ye, et al.
Published: (2023-05-01)

Prevalence of pulmonary hypertension in children with obstructive sleep apnea living at high altitude
by: Elida Duenas-Meza, et al.
Published: (2024-12-01)

Comparative efficacy of various hypoxic training paradigms on maximal oxygen consumption: A systematic review and network meta-analysis
by: Qian Yu, et al.
Published: (2023-10-01)

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
by: Yoomi Chun, et al.
Published: (2021-09-01)

Circulating Microparticles Are Differentially Increased in Lowlanders and Highlanders with High Altitude Induced Pulmonary Hypertension during the Cold Season
by: Akylbek Sydykov, et al.
Published: (2022-09-01)

PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION
by: L. A. Khaisheva, et al.
Published: (2010-10-01)

Ghrelin improves endothelial function and reduces blood pressure in Ang II-induced hypertensive mice: Role of AMPK
by: Juan Deng, et al.
Published: (2023-12-01)

Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice
by: Kathrin Malkmus, et al.
Published: (2022-12-01)

Characteristics of patients with patent ductus arteriosus and/or pulmonary hypertension living at moderate to high altitude and important considerations while performing transcatheter closure
by: Bahri Akdeniz
Published: (2019-09-01)

Perk heterozygosity ameliorates chronic hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in male rats
by: Qingxia Wei, et al.
Published: (2022-01-01)

Endothelial Function and Hypoxic–Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial
by: Irina A. Mandel, et al.
Published: (2023-03-01)

Rehabilitation in patients with pulmonary arterial hypertension
by: Stephan Keusch, et al.
Published: (2017-07-01)

Factors to Consider to Study Preductal Oxygen Saturation Targets in Neonatal Pulmonary Hypertension
by: Heather Siefkes, et al.
Published: (2022-03-01)