Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice

Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice

BackgroundProlonged exposure to general anesthesia (GA) results in long-lasting cognitive impairment, especially during critical stages of brain development. An exaggerated neuroinflammation induced by anesthesia is generally considered to be a key cause of cognitive impairment.Materials and methods...

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Bibliographic Details
Main Authors: Xiaojun Zhang, Wensi Wu, Zhenzhen Zheng, Liang Li, Junjun Chen, Junying Zhong, Le Zhao, Jiawei Chen, Zhi Wang, Fanqing Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Neuroscience
Subjects:
mast cell
disodium cromoglycate
long-term cognitive impairment
general anesthesia
neonatal mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.990333/full

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