Kidney Issues Associated with COVID-19 Disease
Infection with SARS-CoV-2 and the resulting COVID-19 can cause both lung and kidney damage. SARS-CoV-2 can directly infect renal cells expressing ACE2 receptors, resulting in kidney damage, and acute kidney injury (AKI) has been reported in COVID-19 hospitalized patients. The pathophysiology of COVI...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Encyclopedia |
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| Online Access: | https://www.mdpi.com/2673-8392/3/3/79 |
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| author | Periklis Dousdampanis Athanasia Mouzaki Konstantina Trigka Ioannis Stefanidis Konstantinos-Eugenios Galanopoulos Ioannis-Santo Siavelis Dionysia Stathopoulou Stelios F. Assimakopoulos |
| author_facet | Periklis Dousdampanis Athanasia Mouzaki Konstantina Trigka Ioannis Stefanidis Konstantinos-Eugenios Galanopoulos Ioannis-Santo Siavelis Dionysia Stathopoulou Stelios F. Assimakopoulos |
| author_sort | Periklis Dousdampanis |
| collection | DOAJ |
| description | Infection with SARS-CoV-2 and the resulting COVID-19 can cause both lung and kidney damage. SARS-CoV-2 can directly infect renal cells expressing ACE2 receptors, resulting in kidney damage, and acute kidney injury (AKI) has been reported in COVID-19 hospitalized patients. The pathophysiology of COVID-19-associated AKI is multifactorial. Local and systemic inflammation, immune system dysregulation, blood coagulation disorders, and activation of the renin-angiotensin-aldosterone system (RAAS) are factors that contribute to the development of AKI in COVID 19 disease. COVID-19 patients with kidney involvement have a poor prognosis, and patients with chronic kidney disease (CKD) infected with SARS-CoV-2 have an increased mortality risk. CKD patients with COVID-19 may develop end-stage renal disease (ESRD) requiring dialysis. In particular, patients infected with SARS-CoV-2 and requiring dialysis, as well as patients who have undergone kidney transplantation, have an increased risk of mortality and require special consideration. Nephrologists and infectious disease specialists face several clinical dilemmas in the prophylaxis and treatment of CKD patients with COVID-19. This entry presents recent data showing the effects of COVID-19 on the kidneys and CKD patients and the challenges in the management of CKD patients with COVID-19, and discusses treatment strategies for these patients. |
| first_indexed | 2024-03-10T22:50:37Z |
| format | Article |
| id | doaj.art-c7b1dd8983ea40b1a1a5edcdbee74b52 |
| institution | Directory Open Access Journal |
| issn | 2673-8392 |
| language | English |
| last_indexed | 2024-03-10T22:50:37Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Encyclopedia |
| spelling | doaj.art-c7b1dd8983ea40b1a1a5edcdbee74b522023-11-19T10:24:29ZengMDPI AGEncyclopedia2673-83922023-08-01331085110410.3390/encyclopedia3030079Kidney Issues Associated with COVID-19 DiseasePeriklis Dousdampanis0Athanasia Mouzaki1Konstantina Trigka2Ioannis Stefanidis3Konstantinos-Eugenios Galanopoulos4Ioannis-Santo Siavelis5Dionysia Stathopoulou6Stelios F. Assimakopoulos7Department of Nephrology, Saint Andrews General Hospital of Patras, 26222 Patras, GreeceDivision of Hematology, Department of Internal Medicine, Medical School, University of Patras, 26504 Patras, GreeceHemodialysis Unit Kyanous Stavros Patras, 26331 Patras, GreeceDepartment of Nephrology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41223 Larisa, GreeceDepartment of Nuclear Medicine, Saint Andrews General Hospital of Patras, 26222 Patras, GreeceDepartment of Internal Medicine, Medical School, University of Patras, 26504 Patras, GreeceDepartment of Cardiology, Saint Andrews General Hospital of Patras, 26222 Patras, GreeceDivision of Infectious Diseases, Department of Internal Medicine, Medical School, University of Patras, 26504 Patras, GreeceInfection with SARS-CoV-2 and the resulting COVID-19 can cause both lung and kidney damage. SARS-CoV-2 can directly infect renal cells expressing ACE2 receptors, resulting in kidney damage, and acute kidney injury (AKI) has been reported in COVID-19 hospitalized patients. The pathophysiology of COVID-19-associated AKI is multifactorial. Local and systemic inflammation, immune system dysregulation, blood coagulation disorders, and activation of the renin-angiotensin-aldosterone system (RAAS) are factors that contribute to the development of AKI in COVID 19 disease. COVID-19 patients with kidney involvement have a poor prognosis, and patients with chronic kidney disease (CKD) infected with SARS-CoV-2 have an increased mortality risk. CKD patients with COVID-19 may develop end-stage renal disease (ESRD) requiring dialysis. In particular, patients infected with SARS-CoV-2 and requiring dialysis, as well as patients who have undergone kidney transplantation, have an increased risk of mortality and require special consideration. Nephrologists and infectious disease specialists face several clinical dilemmas in the prophylaxis and treatment of CKD patients with COVID-19. This entry presents recent data showing the effects of COVID-19 on the kidneys and CKD patients and the challenges in the management of CKD patients with COVID-19, and discusses treatment strategies for these patients.https://www.mdpi.com/2673-8392/3/3/79chronic kidney diseaseCOVID-19hemodialysiskidney transplantationperitoneal dialysisSARS-CoV-2 |
| spellingShingle | Periklis Dousdampanis Athanasia Mouzaki Konstantina Trigka Ioannis Stefanidis Konstantinos-Eugenios Galanopoulos Ioannis-Santo Siavelis Dionysia Stathopoulou Stelios F. Assimakopoulos Kidney Issues Associated with COVID-19 Disease Encyclopedia chronic kidney disease COVID-19 hemodialysis kidney transplantation peritoneal dialysis SARS-CoV-2 |
| title | Kidney Issues Associated with COVID-19 Disease |
| title_full | Kidney Issues Associated with COVID-19 Disease |
| title_fullStr | Kidney Issues Associated with COVID-19 Disease |
| title_full_unstemmed | Kidney Issues Associated with COVID-19 Disease |
| title_short | Kidney Issues Associated with COVID-19 Disease |
| title_sort | kidney issues associated with covid 19 disease |
| topic | chronic kidney disease COVID-19 hemodialysis kidney transplantation peritoneal dialysis SARS-CoV-2 |
| url | https://www.mdpi.com/2673-8392/3/3/79 |
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