The effect of <it>Aloe ferox </it>Mill. in the treatment of loperamide-induced constipation in Wistar rats
<p>Abstract</p> <p>Background</p> <p>Constipation is the most common gastrointestinal complaint all over the world and it is a risk factor of colorectal cancer. In this study, the efficacy of aqueous leaf extract of <it>Aloe </it><it>ferox </it>M...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-08-01
|
| Series: | BMC Gastroenterology |
| Online Access: | http://www.biomedcentral.com/1471-230X/10/95 |
| _version_ | 1818273775147286528 |
|---|---|
| author | Wintola Olubunmi A Sunmonu Taofik O Afolayan Anthony J |
| author_facet | Wintola Olubunmi A Sunmonu Taofik O Afolayan Anthony J |
| author_sort | Wintola Olubunmi A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Constipation is the most common gastrointestinal complaint all over the world and it is a risk factor of colorectal cancer. In this study, the efficacy of aqueous leaf extract of <it>Aloe </it><it>ferox </it>Mill. was studied against loperamide-induced constipation in Wistar rats.</p> <p>Methods</p> <p>Constipation was induced by oral administration of loperamide (3 mg/kg body weight) while the control rats received normal saline. The constipated rats were treated with 50, 100 and 200 mg/kg body weight/day of the extract for 7 days during which the feeding characteristics, body weight, fecal properties and gastrointestinal transit ratio were monitored.</p> <p>Results</p> <p>The extract improved intestinal motility, increased fecal volume and normalized body weight in the constipated rats, which are indications of laxative property of the herb with the 200 mg/kg body weight of the extract showing the best efficacy.</p> <p>Conclusion</p> <p>The effect of the extract compares favourably well with senokot, a standard laxative drug. These findings have therefore, lent scientific credence to the folkloric use of the herb as a laxative agent by the people of the Eastern Cape of South Africa.</p> |
| first_indexed | 2024-12-12T22:03:19Z |
| format | Article |
| id | doaj.art-c7b397931da5418491652028c7c0a1fd |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-12T22:03:19Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-c7b397931da5418491652028c7c0a1fd2022-12-22T00:10:28ZengBMCBMC Gastroenterology1471-230X2010-08-011019510.1186/1471-230X-10-95The effect of <it>Aloe ferox </it>Mill. in the treatment of loperamide-induced constipation in Wistar ratsWintola Olubunmi ASunmonu Taofik OAfolayan Anthony J<p>Abstract</p> <p>Background</p> <p>Constipation is the most common gastrointestinal complaint all over the world and it is a risk factor of colorectal cancer. In this study, the efficacy of aqueous leaf extract of <it>Aloe </it><it>ferox </it>Mill. was studied against loperamide-induced constipation in Wistar rats.</p> <p>Methods</p> <p>Constipation was induced by oral administration of loperamide (3 mg/kg body weight) while the control rats received normal saline. The constipated rats were treated with 50, 100 and 200 mg/kg body weight/day of the extract for 7 days during which the feeding characteristics, body weight, fecal properties and gastrointestinal transit ratio were monitored.</p> <p>Results</p> <p>The extract improved intestinal motility, increased fecal volume and normalized body weight in the constipated rats, which are indications of laxative property of the herb with the 200 mg/kg body weight of the extract showing the best efficacy.</p> <p>Conclusion</p> <p>The effect of the extract compares favourably well with senokot, a standard laxative drug. These findings have therefore, lent scientific credence to the folkloric use of the herb as a laxative agent by the people of the Eastern Cape of South Africa.</p>http://www.biomedcentral.com/1471-230X/10/95 |
| spellingShingle | Wintola Olubunmi A Sunmonu Taofik O Afolayan Anthony J The effect of <it>Aloe ferox </it>Mill. in the treatment of loperamide-induced constipation in Wistar rats BMC Gastroenterology |
| title | The effect of <it>Aloe ferox </it>Mill. in the treatment of loperamide-induced constipation in Wistar rats |
| title_full | The effect of <it>Aloe ferox </it>Mill. in the treatment of loperamide-induced constipation in Wistar rats |
| title_fullStr | The effect of <it>Aloe ferox </it>Mill. in the treatment of loperamide-induced constipation in Wistar rats |
| title_full_unstemmed | The effect of <it>Aloe ferox </it>Mill. in the treatment of loperamide-induced constipation in Wistar rats |
| title_short | The effect of <it>Aloe ferox </it>Mill. in the treatment of loperamide-induced constipation in Wistar rats |
| title_sort | effect of it aloe ferox it mill in the treatment of loperamide induced constipation in wistar rats |
| url | http://www.biomedcentral.com/1471-230X/10/95 |
| work_keys_str_mv | AT wintolaolubunmia theeffectofitaloeferoxitmillinthetreatmentofloperamideinducedconstipationinwistarrats AT sunmonutaofiko theeffectofitaloeferoxitmillinthetreatmentofloperamideinducedconstipationinwistarrats AT afolayananthonyj theeffectofitaloeferoxitmillinthetreatmentofloperamideinducedconstipationinwistarrats AT wintolaolubunmia effectofitaloeferoxitmillinthetreatmentofloperamideinducedconstipationinwistarrats AT sunmonutaofiko effectofitaloeferoxitmillinthetreatmentofloperamideinducedconstipationinwistarrats AT afolayananthonyj effectofitaloeferoxitmillinthetreatmentofloperamideinducedconstipationinwistarrats |