The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway
The adamantine derivative SQ109 induces protective pro-inflammatory cytokines and promotes Th1 and Th17-immune responses that inhibit bacterial burden in a tuberculosis mouse model.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03693-2 |
| _version_ | 1828430787204087808 |
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| author | Mona Singh Santosh Kumar Baldeep Singh Preeti Jain Anjna Kumari Isha Pahuja Shivam Chaturvedi Durbaka Vijay Raghava Prasad Ved Prakash Dwivedi Gobardhan Das |
| author_facet | Mona Singh Santosh Kumar Baldeep Singh Preeti Jain Anjna Kumari Isha Pahuja Shivam Chaturvedi Durbaka Vijay Raghava Prasad Ved Prakash Dwivedi Gobardhan Das |
| author_sort | Mona Singh |
| collection | DOAJ |
| description | The adamantine derivative SQ109 induces protective pro-inflammatory cytokines and promotes Th1 and Th17-immune responses that inhibit bacterial burden in a tuberculosis mouse model. |
| first_indexed | 2024-12-10T17:54:07Z |
| format | Article |
| id | doaj.art-c7b5a0e17e0d49ffbc1eb9b73fc391e6 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-10T17:54:07Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-c7b5a0e17e0d49ffbc1eb9b73fc391e62022-12-22T01:39:00ZengNature PortfolioCommunications Biology2399-36422022-07-015111010.1038/s42003-022-03693-2The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathwayMona Singh0Santosh Kumar1Baldeep Singh2Preeti Jain3Anjna Kumari4Isha Pahuja5Shivam Chaturvedi6Durbaka Vijay Raghava Prasad7Ved Prakash Dwivedi8Gobardhan Das9Special Centre for Molecular Medicine, Jawaharlal Nehru UniversityImmunobiology Group, International Centre for Genetic Engineering and BiotechnologySpecial Centre for Molecular Medicine, Jawaharlal Nehru UniversitySpecial Centre for Molecular Medicine, Jawaharlal Nehru UniversityImmunobiology Group, International Centre for Genetic Engineering and BiotechnologyImmunobiology Group, International Centre for Genetic Engineering and BiotechnologyImmunobiology Group, International Centre for Genetic Engineering and BiotechnologyDepartment of Microbiology, Yogi Vemana UniversityImmunobiology Group, International Centre for Genetic Engineering and BiotechnologySpecial Centre for Molecular Medicine, Jawaharlal Nehru UniversityThe adamantine derivative SQ109 induces protective pro-inflammatory cytokines and promotes Th1 and Th17-immune responses that inhibit bacterial burden in a tuberculosis mouse model.https://doi.org/10.1038/s42003-022-03693-2 |
| spellingShingle | Mona Singh Santosh Kumar Baldeep Singh Preeti Jain Anjna Kumari Isha Pahuja Shivam Chaturvedi Durbaka Vijay Raghava Prasad Ved Prakash Dwivedi Gobardhan Das The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway Communications Biology |
| title | The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway |
| title_full | The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway |
| title_fullStr | The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway |
| title_full_unstemmed | The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway |
| title_short | The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway |
| title_sort | 1 2 ethylenediamine sq109 protects against tuberculosis by promoting m1 macrophage polarization through the p38 mapk pathway |
| url | https://doi.org/10.1038/s42003-022-03693-2 |
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