The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway

The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway

The adamantine derivative SQ109 induces protective pro-inflammatory cytokines and promotes Th1 and Th17-immune responses that inhibit bacterial burden in a tuberculosis mouse model.

Bibliographic Details
Main Authors:	Mona Singh, Santosh Kumar, Baldeep Singh, Preeti Jain, Anjna Kumari, Isha Pahuja, Shivam Chaturvedi, Durbaka Vijay Raghava Prasad, Ved Prakash Dwivedi, Gobardhan Das
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-07-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-022-03693-2

Similar Items

Improved Synthesis of the Antitubercular Agent SQ109
by: Marianna Stampolaki, et al.
Published: (2021-12-01)

Biapenem, a Carbapenem Antibiotic, Elicits Mycobacteria Specific Immune Responses and Reduces the Recurrence of Tuberculosis
by: Isha Pahuja, et al.
Published: (2023-08-01)

Berberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis
by: Isha Pahuja, et al.
Published: (2023-03-01)

Berberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis.
by: Isha Pahuja, et al.
Published: (2023-03-01)

In Vivo Efficacy of SQ109 against <i>Leishmania donovani</i>, <i>Trypanosoma</i> spp. and <i>Toxoplasma gondii</i> and In Vitro Activity of SQ109 Metabolites
by: Kyung-Hwa Baek, et al.
Published: (2022-03-01)

In vitro characterization of the anti-bacterial activity of SQ109 against Helicobacter pylori.
by: Morris O Makobongo, et al.
Published: (2013-01-01)

Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.
by: Dhiraj Kumar Singh, et al.
Published: (2020-09-01)

Correction: Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.
by: Dhiraj Kumar Singh, et al.
Published: (2021-08-01)

EFFICIENCY AND SAFETY OF CHEMOTHERAPY REGIMEN WITH SQ109 IN THOSE SUFFERING FROM MULTIPLE DRUG RESISTANT TUBERCULOSIS
by: S. E. Borisov, et al.
Published: (2018-04-01)

Deciphering the possible role of MmpL7 efflux pump in SQ109 resistance in Mycobacterium tuberculosis
by: Wei Jing, et al.
Published: (2024-09-01)

ADVERSE SIDE EFFECTS OF TUBERCULOSIS ETIOTROPIC TREATMENT REGIMENS CONTAINING THE NEW ANTI-TUBERCULOSIS DRUG OF SQ109
by: S. E. Borisov
Published: (2018-08-01)

Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis
by: Meetu Agarwal, et al.
Published: (2024-08-01)

SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis
by: Ashima Bhaskar, et al.
Published: (2023-05-01)

Crystal structure of pentakis(ethylenediamine-κ2N,N′)lanthanum(III) trichloride–ethylenediamine–dichloromethane (1/1/1)
by: Hope T. Sartain, et al.
Published: (2014-11-01)

Intranasal immunization with peptide-based immunogenic complex enhances BCG vaccine efficacy in a murine model of tuberculosis
by: Santosh Kumar, et al.
Published: (2021-02-01)

Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals
by: Samreen Fatima, et al.
Published: (2021-12-01)

Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide.
by: Robert S Wallis, et al.
Published: (2012-01-01)

Preparation of Ethylenediamine by Ammonolysis of 1,2-Dichloroethane in Nonaqueous Media
by: Mohammad Rahimizadeh, et al.
Published: (1995-12-01)

MmpL3 Inhibition as a Promising Approach to Develop Novel Therapies against Tuberculosis: A Spotlight on SQ109, Clinical Studies, and Patents Literature
by: Mohd. Imran, et al.
Published: (2022-11-01)

LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
by: Hanbing An, et al.
Published: (2011-01-01)

Revolusi IQ.EQ.SQ /
by: 280426 Taufik Pasiak
Published: (2008)

p38gamma and p38delta mitogen activated protein kinases (MAPKs), new stars in the MAPK galaxy
by: Alejandra eEscós, et al.
Published: (2016-04-01)

BMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway
by: Jun Yu, et al.
Published: (2021-04-01)

p38 MAPK signalling in osteoblast differentiation
by: Edgardo eRodríguez-Carballo, et al.
Published: (2016-05-01)

Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.
by: Lasa, M, et al.
Published: (2002)

The crystal structure of trans-dichlorido-(ethylenediamine-κ 2 N,N′)-bis(triphenylphosphine-κ 1 P)ruthenium(II), C38H38Cl2N2P2Ru
by: Ndlangamandla Nqobile G., et al.
Published: (2022-12-01)

RIOK-1 Is a Suppressor of the p38 MAPK Innate Immune Pathway in Caenorhabditis elegans
by: Yi-Wei Chen, et al.
Published: (2018-04-01)

SqEK – Squatting Everywhere Kollective
Published: (2019-04-01)

SPIRITUAL QUOTIENT (SQ): THE ULTIMATE INTELLIGENCE
by: Rus'an Rus'an
Published: (2013-07-01)

Variations in the strength of the Sq current system
by: R. J. Stening

Variations in the strength of the Sq current system
by: R. J. Stening
Published: (1995-06-01)

Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation.
by: Chih-Chung Lin, et al.
Published: (2015-01-01)

Αἰῶνος λιταί (Nonn. Dion. 7.1-109)
by: Konstantinos Spanoudakis
Published: (2012-07-01)

p38 MAPK, microglial signaling, and neuropathic pain
by: Suter Marc R, et al.
Published: (2007-11-01)

p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage
by: Mirta Mittelstedt Leal de Sousa, et al.
Published: (2017-07-01)

Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon.
by: Claire Rooney, et al.
Published: (2016-01-01)

Abnormal development of tapetum and microspores induced by chemical hybridization agent SQ-1 in wheat.
by: Shuping Wang, et al.
Published: (2015-01-01)

The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages
by: Debprasad Chattopadhyay, et al.
Published: (2017-05-01)

Functionalization of reduced graphene oxide with ethylenediamine /
by: Nurul Sazwani Jamari, 1992-, author
Published: (2015)

Functionalization of reduced graphene oxide with ethylenediamine /
by: Nurul Sazwani Jamari, 1992-, author, et al.
Published: (2015)