Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease
Objective To investigate the correlation between the counts of CD3+, CD4+, and CD8+ T cells in peripheral blood as well as the ratio of CD4+/CD8+ T cells and the renal endpoint events (renal substitutive therapy) in patients with chronic kidney disease (CKD), and to determine whether these T cell pa...
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Editorial Office of Journal of Third Military Medical University
2021-03-01
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Series: | Di-san junyi daxue xuebao |
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Online Access: | https://aammt.tmmu.edu.cn/Upload/rhtml/202008018.htm |
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author | QIAO Yu XIONG Jiachuan ZHAO Jinghong |
author_facet | QIAO Yu XIONG Jiachuan ZHAO Jinghong |
author_sort | QIAO Yu |
collection | DOAJ |
description | Objective To investigate the correlation between the counts of CD3+, CD4+, and CD8+ T cells in peripheral blood as well as the ratio of CD4+/CD8+ T cells and the renal endpoint events (renal substitutive therapy) in patients with chronic kidney disease (CKD), and to determine whether these T cell parameters are prognostic indicators for pre-dialysis CKD patients. Methods A total of 568 pre-dialysis patients with primary CKD at stage 3~5 admitted in our hospital from March 2015 to January 2019 were enrolled and followed up in this study. Immunofluorescence flow cytometry was adopted to detect the counts of CD3+, CD4+ and CD8+ T cells, and the ratio of CD4+/CD8+ T cells was calculated. The CKD patients then were divided into normal- and low-level groups of CD3+, CD4+ and CD8+ T cell counts, according to the clinical reference values. The renal endpoint event was defined as initiation of a renal substitutive therapy duo to irreversible deterioration of kidney function, including peritoneal dialysis, hemodialysis, and kidney transplantation. Kaplan-Meier analysis was used to compare the survival time between the 2 groups. Cox regression model was adopted to analyze the risk factors associated with CKD progression. Results There were eventually 240 patients (42.25%) receiving renal substitutive therapy during a mean follow-up of 2.25 years. Kaplan-Meier analysis showed that lower counts of CD3+, CD4+ and CD8+ T cells were independently associated with higher occurrence of the renal endpoint events. Cox regression model suggested that the low-level groups of the above 3 kinds of T cells had significantly higher risks in progression into the endpoint events (HR=1.575, 1.511, 1.583). After multivariable adjustment, the risk of the endpoint events remained increased in patients from the low-level group (HR=1.803, 1.945, 2.010). Conclusion The reduction of CD3+, CD4+ and CD8+ T cells in peripheral blood is closely related to the occurrence of renal substitutive therapy, which might be used as a predictive factor of renal outcome for CKD patients at pre-dialysis stage 3~5. |
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language | zho |
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publishDate | 2021-03-01 |
publisher | Editorial Office of Journal of Third Military Medical University |
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series | Di-san junyi daxue xuebao |
spelling | doaj.art-c7b97643daa445088fc58d15bf812c482022-12-21T20:18:09ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042021-03-0143543844510.16016/j.1000-5404.202008018Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney diseaseQIAO Yu0 XIONG Jiachuan1ZHAO Jinghong2Department of Nephrology, Kidney Center of PLA, Chongqing Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China Department of Nephrology, Kidney Center of PLA, Chongqing Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China Department of Nephrology, Kidney Center of PLA, Chongqing Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China Objective To investigate the correlation between the counts of CD3+, CD4+, and CD8+ T cells in peripheral blood as well as the ratio of CD4+/CD8+ T cells and the renal endpoint events (renal substitutive therapy) in patients with chronic kidney disease (CKD), and to determine whether these T cell parameters are prognostic indicators for pre-dialysis CKD patients. Methods A total of 568 pre-dialysis patients with primary CKD at stage 3~5 admitted in our hospital from March 2015 to January 2019 were enrolled and followed up in this study. Immunofluorescence flow cytometry was adopted to detect the counts of CD3+, CD4+ and CD8+ T cells, and the ratio of CD4+/CD8+ T cells was calculated. The CKD patients then were divided into normal- and low-level groups of CD3+, CD4+ and CD8+ T cell counts, according to the clinical reference values. The renal endpoint event was defined as initiation of a renal substitutive therapy duo to irreversible deterioration of kidney function, including peritoneal dialysis, hemodialysis, and kidney transplantation. Kaplan-Meier analysis was used to compare the survival time between the 2 groups. Cox regression model was adopted to analyze the risk factors associated with CKD progression. Results There were eventually 240 patients (42.25%) receiving renal substitutive therapy during a mean follow-up of 2.25 years. Kaplan-Meier analysis showed that lower counts of CD3+, CD4+ and CD8+ T cells were independently associated with higher occurrence of the renal endpoint events. Cox regression model suggested that the low-level groups of the above 3 kinds of T cells had significantly higher risks in progression into the endpoint events (HR=1.575, 1.511, 1.583). After multivariable adjustment, the risk of the endpoint events remained increased in patients from the low-level group (HR=1.803, 1.945, 2.010). Conclusion The reduction of CD3+, CD4+ and CD8+ T cells in peripheral blood is closely related to the occurrence of renal substitutive therapy, which might be used as a predictive factor of renal outcome for CKD patients at pre-dialysis stage 3~5.https://aammt.tmmu.edu.cn/Upload/rhtml/202008018.htmchronic kidney diseaset lymphocyte subpopulationrenal endpoint events |
spellingShingle | QIAO Yu XIONG Jiachuan ZHAO Jinghong Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease Di-san junyi daxue xuebao chronic kidney disease t lymphocyte subpopulation renal endpoint events |
title | Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease |
title_full | Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease |
title_fullStr | Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease |
title_full_unstemmed | Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease |
title_short | Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease |
title_sort | reduction of t cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease |
topic | chronic kidney disease t lymphocyte subpopulation renal endpoint events |
url | https://aammt.tmmu.edu.cn/Upload/rhtml/202008018.htm |
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