Effect of obstructive cholestasis on sex axis in the adult male rats
Background and Objective: Obstructive cholestasis is associated with overproduction of some materials such as endogenous opioids (EOP) and nitric oxide (NO) in the blood streams. Physiology of sex axis hormones could be affected by some of these changes. This study was done to investigate the relati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Babol University of Medical Sciences
2003-10-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/article-1-2743-en.html |
| _version_ | 1818900847280521216 |
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| author | E Nasiri MH Noori AR Dehpour M Barbarestani AK Amir Zargar M Akbari M Pour Ghasem |
| author_facet | E Nasiri MH Noori AR Dehpour M Barbarestani AK Amir Zargar M Akbari M Pour Ghasem |
| author_sort | E Nasiri |
| collection | DOAJ |
| description | Background and Objective: Obstructive cholestasis is associated with overproduction of some materials such as endogenous opioids (EOP) and nitric oxide (NO) in the blood streams. Physiology of sex axis hormones could be affected by some of these changes. This study was done to investigate the relationship between obstructive cholestasis and sex axis in adult male rats. Methods: To study the topic, three groups of animals were used: No-surgery, sham-surgery, and surgical ligation of the bile duct. After 3 weeks, all animals were killed by ether. Serum concentration levels of inhibin B, FSH and LH were determined by ELISA and RIA, respectively. Findings: The level of inhibin B was significantly higher in cholestasis than control and sham, and serum FSH and LH were significantly higher in control and sham than cholestasis (P<0.05). Conclusion: The results showed that obstructive cholestasis decreased the levels of serum gonadotropins but in did not damage testicular functions. |
| first_indexed | 2024-12-19T20:10:22Z |
| format | Article |
| id | doaj.art-c7b99bcf56e94e8caa976b7e700f79cf |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-12-19T20:10:22Z |
| publishDate | 2003-10-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-c7b99bcf56e94e8caa976b7e700f79cf2022-12-21T20:07:19ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702003-10-0154710Effect of obstructive cholestasis on sex axis in the adult male ratsE Nasiri0MH Noori1AR Dehpour2M Barbarestani3AK Amir Zargar4M Akbari5M Pour Ghasem6 Background and Objective: Obstructive cholestasis is associated with overproduction of some materials such as endogenous opioids (EOP) and nitric oxide (NO) in the blood streams. Physiology of sex axis hormones could be affected by some of these changes. This study was done to investigate the relationship between obstructive cholestasis and sex axis in adult male rats. Methods: To study the topic, three groups of animals were used: No-surgery, sham-surgery, and surgical ligation of the bile duct. After 3 weeks, all animals were killed by ether. Serum concentration levels of inhibin B, FSH and LH were determined by ELISA and RIA, respectively. Findings: The level of inhibin B was significantly higher in cholestasis than control and sham, and serum FSH and LH were significantly higher in control and sham than cholestasis (P<0.05). Conclusion: The results showed that obstructive cholestasis decreased the levels of serum gonadotropins but in did not damage testicular functions.http://jbums.org/article-1-2743-en.htmlobstructive cholestasisfshlhinhibin b |
| spellingShingle | E Nasiri MH Noori AR Dehpour M Barbarestani AK Amir Zargar M Akbari M Pour Ghasem Effect of obstructive cholestasis on sex axis in the adult male rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul obstructive cholestasis fsh lh inhibin b |
| title | Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_full | Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_fullStr | Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_full_unstemmed | Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_short | Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_sort | effect of obstructive cholestasis on sex axis in the adult male rats |
| topic | obstructive cholestasis fsh lh inhibin b |
| url | http://jbums.org/article-1-2743-en.html |
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