Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond <i>Pafah1b1(Lis1)</i>, <i>Crk</i> and <i>Ywhae(14-3-3ε)</i>
The 17p13.3 chromosome region is often deleted or duplicated in humans, resulting in severe neurodevelopmental disorders such as Miller–Dieker syndrome (MDS) and 17p13.3 duplication syndrome. Lissencephaly can also be caused by gene mutations or deletions of a small piece of the 17p13.3 region, incl...
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MDPI AG
2021-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/1/56 |
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| author | Xiaonan Liu Sarah A. Bennison Lozen Robinson Kazuhito Toyo-oka |
| author_facet | Xiaonan Liu Sarah A. Bennison Lozen Robinson Kazuhito Toyo-oka |
| author_sort | Xiaonan Liu |
| collection | DOAJ |
| description | The 17p13.3 chromosome region is often deleted or duplicated in humans, resulting in severe neurodevelopmental disorders such as Miller–Dieker syndrome (MDS) and 17p13.3 duplication syndrome. Lissencephaly can also be caused by gene mutations or deletions of a small piece of the 17p13.3 region, including a single gene or a few genes. <i>PAFAH1B1</i> gene, coding for LIS1 protein, is a responsible gene for lissencephaly and MDS and regulates neuronal migration by controlling microtubules (MTs) and cargo transport along MTs via dynein. CRK is a downstream regulator of the reelin signaling pathways and regulates neuronal migration. <i>YWHAE</i>, coding for 14-3-3ε, is also responsible for MDS and regulates neuronal migration by binding to LIS1-interacting protein, NDEL1. Although these three proteins are known to be responsible for neuronal migration defects in MDS, there are 23 other genes in the MDS critical region on chromosome 17p13.3, and little is known about their functions in neurodevelopment, especially in neuronal migration. This review will summarize the recent progress on the functions of LIS1, CRK, and 14-3-3ε and describe the recent findings of other molecules in the MDS critical regions in neuronal migration. |
| first_indexed | 2024-03-10T01:49:26Z |
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| id | doaj.art-c7ba11bb3f2540a0a10e30625e601fea |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T01:49:26Z |
| publishDate | 2021-12-01 |
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| spelling | doaj.art-c7ba11bb3f2540a0a10e30625e601fea2023-11-23T13:09:26ZengMDPI AGBrain Sciences2076-34252021-12-011215610.3390/brainsci12010056Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond <i>Pafah1b1(Lis1)</i>, <i>Crk</i> and <i>Ywhae(14-3-3ε)</i>Xiaonan Liu0Sarah A. Bennison1Lozen Robinson2Kazuhito Toyo-oka3Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19129, USADepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USADepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USADepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USAThe 17p13.3 chromosome region is often deleted or duplicated in humans, resulting in severe neurodevelopmental disorders such as Miller–Dieker syndrome (MDS) and 17p13.3 duplication syndrome. Lissencephaly can also be caused by gene mutations or deletions of a small piece of the 17p13.3 region, including a single gene or a few genes. <i>PAFAH1B1</i> gene, coding for LIS1 protein, is a responsible gene for lissencephaly and MDS and regulates neuronal migration by controlling microtubules (MTs) and cargo transport along MTs via dynein. CRK is a downstream regulator of the reelin signaling pathways and regulates neuronal migration. <i>YWHAE</i>, coding for 14-3-3ε, is also responsible for MDS and regulates neuronal migration by binding to LIS1-interacting protein, NDEL1. Although these three proteins are known to be responsible for neuronal migration defects in MDS, there are 23 other genes in the MDS critical region on chromosome 17p13.3, and little is known about their functions in neurodevelopment, especially in neuronal migration. This review will summarize the recent progress on the functions of LIS1, CRK, and 14-3-3ε and describe the recent findings of other molecules in the MDS critical regions in neuronal migration.https://www.mdpi.com/2076-3425/12/1/56neuronal migrationchromosome 17p13.3lissencephalyMiller–Dieker syndrome<i>PAFAH1B1</i> (LIS1)<i>YWHAE</i> (14-3-3ε) |
| spellingShingle | Xiaonan Liu Sarah A. Bennison Lozen Robinson Kazuhito Toyo-oka Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond <i>Pafah1b1(Lis1)</i>, <i>Crk</i> and <i>Ywhae(14-3-3ε)</i> Brain Sciences neuronal migration chromosome 17p13.3 lissencephaly Miller–Dieker syndrome <i>PAFAH1B1</i> (LIS1) <i>YWHAE</i> (14-3-3ε) |
| title | Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond <i>Pafah1b1(Lis1)</i>, <i>Crk</i> and <i>Ywhae(14-3-3ε)</i> |
| title_full | Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond <i>Pafah1b1(Lis1)</i>, <i>Crk</i> and <i>Ywhae(14-3-3ε)</i> |
| title_fullStr | Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond <i>Pafah1b1(Lis1)</i>, <i>Crk</i> and <i>Ywhae(14-3-3ε)</i> |
| title_full_unstemmed | Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond <i>Pafah1b1(Lis1)</i>, <i>Crk</i> and <i>Ywhae(14-3-3ε)</i> |
| title_short | Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond <i>Pafah1b1(Lis1)</i>, <i>Crk</i> and <i>Ywhae(14-3-3ε)</i> |
| title_sort | responsible genes for neuronal migration in the chromosome 17p13 3 beyond i pafah1b1 lis1 i i crk i and i ywhae 14 3 3ε i |
| topic | neuronal migration chromosome 17p13.3 lissencephaly Miller–Dieker syndrome <i>PAFAH1B1</i> (LIS1) <i>YWHAE</i> (14-3-3ε) |
| url | https://www.mdpi.com/2076-3425/12/1/56 |
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