Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases
Plant-derived compounds have recently attracted greater interest in the field of new therapeutic agent development. These compounds have been widely screened for their pharmacological effects. Polyphenols, such as soy-derived isoflavones, also called phytoestrogens, have been extensively studied due...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-10-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/21/3892 |
| _version_ | 1818160187628847104 |
|---|---|
| author | Prakash Thangavel Abraham Puga-Olguín Juan F. Rodríguez-Landa Rossana C. Zepeda |
| author_facet | Prakash Thangavel Abraham Puga-Olguín Juan F. Rodríguez-Landa Rossana C. Zepeda |
| author_sort | Prakash Thangavel |
| collection | DOAJ |
| description | Plant-derived compounds have recently attracted greater interest in the field of new therapeutic agent development. These compounds have been widely screened for their pharmacological effects. Polyphenols, such as soy-derived isoflavones, also called phytoestrogens, have been extensively studied due to their ability to inhibit carcinogenesis. These compounds are chemically similar to 17β-estradiol, and mimic the binding of estrogens to its receptors, exerting estrogenic effects in target organs. Genistein is an isoflavone derived from soy-rich products and accounts for about 60% of total isoflavones found in soybeans. Genistein has been reported to exhibit several biological effects, such as anti-tumor activity (inhibition of cell proliferation, regulation of the cell cycle, induction of apoptosis), improvement of glucose metabolism, impairment of angiogenesis in both hormone-related and hormone-unrelated cancer cells, reduction of peri-menopausal and postmenopausal hot flashes, and modulation of antioxidant effects. Additionally, epidemiological and clinical studies have reported health benefits of genistein in many chronic diseases, such as cardiovascular disease, diabetes, and osteoporosis, and aid in the amelioration of typical menopausal symptoms, such as anxiety and depression. Although the biological effects are promising, certain limitations, such as low bioavailability, biological estrogenic activity, and effects on target organs, have limited the clinical applications of genistein to some extent. Moreover, studies report that modification of its molecular structure may eliminate the biological estrogenic activity and its effects on target organs. In this review, we summarize the potential benefits of genistein on menopause symptoms and menopause-related diseases like cardiovascular, osteoporosis, obesity, diabetes, anxiety, depression, and breast cancer. |
| first_indexed | 2024-12-11T15:57:54Z |
| format | Article |
| id | doaj.art-c7ba81fac9014f4c98c517b3213fe65b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T15:57:54Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c7ba81fac9014f4c98c517b3213fe65b2022-12-22T00:59:22ZengMDPI AGMolecules1420-30492019-10-012421389210.3390/molecules24213892molecules24213892Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related DiseasesPrakash Thangavel0Abraham Puga-Olguín1Juan F. Rodríguez-Landa2Rossana C. Zepeda3Programa de Posgrado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa C.P. 91190, Veracruz, MexicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa C.P. 91190, Veracruz, MexicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa C.P. 91190, Veracruz, MexicoCentro de Investigaciones Biomédicas, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa C.P. 91190, Veracruz, MexicoPlant-derived compounds have recently attracted greater interest in the field of new therapeutic agent development. These compounds have been widely screened for their pharmacological effects. Polyphenols, such as soy-derived isoflavones, also called phytoestrogens, have been extensively studied due to their ability to inhibit carcinogenesis. These compounds are chemically similar to 17β-estradiol, and mimic the binding of estrogens to its receptors, exerting estrogenic effects in target organs. Genistein is an isoflavone derived from soy-rich products and accounts for about 60% of total isoflavones found in soybeans. Genistein has been reported to exhibit several biological effects, such as anti-tumor activity (inhibition of cell proliferation, regulation of the cell cycle, induction of apoptosis), improvement of glucose metabolism, impairment of angiogenesis in both hormone-related and hormone-unrelated cancer cells, reduction of peri-menopausal and postmenopausal hot flashes, and modulation of antioxidant effects. Additionally, epidemiological and clinical studies have reported health benefits of genistein in many chronic diseases, such as cardiovascular disease, diabetes, and osteoporosis, and aid in the amelioration of typical menopausal symptoms, such as anxiety and depression. Although the biological effects are promising, certain limitations, such as low bioavailability, biological estrogenic activity, and effects on target organs, have limited the clinical applications of genistein to some extent. Moreover, studies report that modification of its molecular structure may eliminate the biological estrogenic activity and its effects on target organs. In this review, we summarize the potential benefits of genistein on menopause symptoms and menopause-related diseases like cardiovascular, osteoporosis, obesity, diabetes, anxiety, depression, and breast cancer.https://www.mdpi.com/1420-3049/24/21/3892hormone replacement therapydiabetesobesitywomancancerosteoporosiscardiovascular diseaseshot flashesmenopause |
| spellingShingle | Prakash Thangavel Abraham Puga-Olguín Juan F. Rodríguez-Landa Rossana C. Zepeda Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases Molecules hormone replacement therapy diabetes obesity woman cancer osteoporosis cardiovascular diseases hot flashes menopause |
| title | Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases |
| title_full | Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases |
| title_fullStr | Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases |
| title_full_unstemmed | Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases |
| title_short | Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases |
| title_sort | genistein as potential therapeutic candidate for menopausal symptoms and other related diseases |
| topic | hormone replacement therapy diabetes obesity woman cancer osteoporosis cardiovascular diseases hot flashes menopause |
| url | https://www.mdpi.com/1420-3049/24/21/3892 |
| work_keys_str_mv | AT prakashthangavel genisteinaspotentialtherapeuticcandidateformenopausalsymptomsandotherrelateddiseases AT abrahampugaolguin genisteinaspotentialtherapeuticcandidateformenopausalsymptomsandotherrelateddiseases AT juanfrodriguezlanda genisteinaspotentialtherapeuticcandidateformenopausalsymptomsandotherrelateddiseases AT rossanaczepeda genisteinaspotentialtherapeuticcandidateformenopausalsymptomsandotherrelateddiseases |