Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

Ferroptosis is a form of cell death primed by iron and lipid hydroperoxides and prevented by GPx4. Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic antioxidants. Previous studies on the antioxidant efficiency of fer-1 adopted kinetic tests where a diazo compound generat...

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Bibliographic Details
Main Authors: Giovanni Miotto, Monica Rossetto, Maria Luisa Di Paolo, Laura Orian, Rina Venerando, Antonella Roveri, Ana-Marija Vučković, Valentina Bosello Travain, Mattia Zaccarin, Lucio Zennaro, Matilde Maiorino, Stefano Toppo, Fulvio Ursini, Giorgio Cozza
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719308389

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